ArticleAnnals of Saudi medicine
Prevalence and association of hyperuricemia with liver function in Saudi Arabia: a large cross-sectional study.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Lipid-Derived Cardiometabolic Indices in Normouricemic and Hyperuricemic Adults: A Retrospective Cross-Sectional Association Study.Healthcare (Basel, Switzerland) · 2025Article
- Knowledge and Treatment of Asymptomatic Hyperuricemia Versus Gout Among Physicians in Saudi Arabia: A Cross-Sectional Survey.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Development and Validation of a Nomogram for Predicting Hyperuricemia in Perimenopausal Women.International journal of general medicine · 2025Article
- Article
- Ethanol Extracts fromFoods (Basel, Switzerland) · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperuricemia is linked to an increased risk of various chronic diseases, but data on the prevalence and association of hyperuricemia with liver function in Saudi Arabia are scarce.
objectivesEvaluate the prevalence, association, and risk measures of hyperuricemia and liver function in the Saudi population.
designRetrospective, cross-sectional analysis.
settingDatabase on large portion of Saudi population. PATIENTS AND
methodsLaboratory data, age, and gender of the studied subjects were collected from Al Borg Diagnostics. Subjects were stratified, based on their uric acid (UA) levels, into three groups: hypouricemic, normouricemic, and hyperuricemic. The association of UA with liver enzymes was examined in all three groups.
main outcome measuresAssociation of serum UA levels with alanine transaminase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP), and total bilirubin (TB). SAMPLE SIZE: 13 314 subjects.
resultsOur study showed that the prevalence of hyperuricemia in the Saudi population is 17.3% (20.3% in males and 15.1% in females). We also found a positive correlation between ALT, AST, and TB with UA levels. The risk of being hyperuricemic was significantly increased in individuals with elevated ALT, AST, and TB. Individuals with elevated ALT, AST, and total TB had a higher chance of having hyperuricemia than those with normal activity. Notably, ALT, AST, and TB had good discriminating capacity for hyperuricemia.
conclusionsHyperuricemia is highly prevalent in the Saudi population and is associated with compromised liver function. However, further studies are needed to elucidate the mechanisms underlying these findings in large prospective cohort studies in different populations. LIMITATIONS: Lack of data on other potential confounding variables.
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