Evidence map›Paper›PMID 38311678›Full record

ArticleScientific reports2024

Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria.

Felicia N Watson, Melanie J Shears, Anya C Kalata, Caroline J Duncombe, A Mariko Seilie, Chris Chavtur, Ethan Conrad, Irene Cruz Talavera, Andrew Raappana, D Noah Sather and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Androgens inhibit protective CD8Nature communications · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Felicia N WatsonGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, 98109, USA.
Melanie J ShearsDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Anya C KalataDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Caroline J DuncombeGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, 98109, USA.
A Mariko SeilieDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Chris ChavturDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Ethan ConradDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Irene Cruz TalaveraDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195, USA.
Andrew RaappanaCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA.
D Noah SatherCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, 98109, USA.
Sumana ChakravartySanaria Inc., 9800 Medical Center Drive, Suite A209, Rockville, MD, 20850, USA.
B Kim Lee SimSanaria Inc., 9800 Medical Center Drive, Suite A209, Rockville, MD, 20850, USA.
Stephen L HoffmanSanaria Inc., 9800 Medical Center Drive, Suite A209, Rockville, MD, 20850, USA.
Moriya TsujiAaron Diamond AIDS Research Center, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Sean C MurphyGraduate Program in Pathobiology, Department of Global Health, University of Washington, Seattle, WA, 98109, USA. murphysc@uw.edu.
University of Washington · USSanaria · USInfectious Disease Research Institute · USAaron Diamond AIDS Research Center · US

Funding

Liver resident memory for malariaR01AI141857 · NIAID · UNIVERSITY OF WASHINGTON · PI MURPHY, SEAN C · 2019 to 2023
$3.9M
Improving the Translational Potential of a Prime-and-Trap Malaria VaccineF31AI169754 · NIAID · UNIVERSITY OF WASHINGTON · PI WATSON, FELICIA · 2022 to 2023
$54k
NIAID NIH HHS F31 AI169754NIAID NIH HHS R01 AI141857
6 · The paper itself

Abstract

Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8

Indexed as

MalariaMalaria VaccinesAdjuvants, ImmunologicAdjuvants, PharmaceuticAnimalsCD8-Positive T-LymphocytesGlycolipidsMiceMice, Inbred BALB CSporozoitesAdjuvants, ImmunologicAdjuvants, PharmaceuticGlycolipidsMalaria Vaccines

Identifiers

PMID38311678
PMCPMC10838921
OpenAlexW4391522121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.