Evidence map›Paper›PMID 38311207›Full record

ArticleOphthalmology. Retina2024

Association of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration.

Sandrine H Künzel, Eliza Broadbent, Philipp T Möller, Moritz Lindner, Lukas Goerdt, Joanna Czauderna, Steffen Schmitz-Valckenberg, Frank G Holz, Maximilian Pfau, Monika Fleckenstein

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Retina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02051998 (Analysis of the Directional Spread of Geographic Atrophy), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02051998 completednot on this map

Analysis of the Directional Spread of Geographic Atrophy (GA) in Patients With Age-related Macular Degeneration (AMD)

TypeobservationalSponsorUniversity Hospital, BonnRan2013 to 2019Enrolled130ConditionsNonexudative Age-related Macular Degeneration
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Visual Function Assessment in Geographic Atrophy: A Review.Clinical & experimental ophthalmology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Geographic atrophy: Understanding the relationship between structure and function.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Sandrine H KünzelDepartment of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address: sandrine.kuenzel@ukbonn.de.
Eliza BroadbentDepartment of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
Philipp T MöllerDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Moritz LindnerDepartment of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps University, Marburg, Germany; Nuffield Laboratory of Ophthalmology, Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Lukas GoerdtDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Joanna CzaudernaDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Steffen Schmitz-ValckenbergDepartment of Ophthalmology, University of Bonn, Bonn, Germany; Department of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
Frank G HolzDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Maximilian PfauInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.
Monika FleckensteinDepartment of Ophthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
University of Bonn · DEUniversity of Utah · USInstitute of Molecular and Clinical Ophthalmology Basel · CHPhilipps University of Marburg · DE

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
The Impact of Non-Exudative Type 1 Macular Neovascularization (MNV) on Age-related Macular Degeneration (AMD) ProgressionR01EY033365 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Monika Fleckenstein · 2022 to 2026
$1.9M
Progression of Early Atrophic Lesions in Age-related Macular degenerationR01EY034965 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Monika Fleckenstein, Steffen Schmitz-Valckenberg · 2023 to 2026
$1.5M
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY033365NEI NIH HHS R01 EY034965
6 · The paper itself

Abstract

objectiveThe primary goal of this study was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients suffering from geographic atrophy (GA) secondary to age-related macular degeneration.

designThis study was designed as a prospective, noninterventional, natural-history study (Directional Spread in Geographic-Atrophy study, NCT02051998). SUBJECTS: The research involved 82 patients with bilateral GA.

methodsThe study examined parameters including GA location as assessed by the ETDRS grid, best-corrected visual acuity, low-luminance visual acuity (LLVA), reading acuity, and speed. These parameters were then correlated with VRQoL, which was gauged using the National Eye Institute Visual Function Questionnaire 25. The analysis method employed was the least absolute shrinkage and selection operator with linear mixed-effects models.

main outcome measuresThe central parameters measured in this study encompassed GA area, VRQoL scores associated with different GA subfields, and the significance of LLVA for foveal-sparing patients.

resultsOn average, patients showed a total GA area of 2.9 ± 1.2 mm

conclusionsThe study's findings point toward the pivotal role of GA location, especially the inner lower and inner left subfields of the BE, in relation to VRQoL in GA patients. The LLVA's importance becomes even more pronounced for foveal-sparing patients. These observations highlight the need for health care professionals to better understand the association between lesion location and patient-reported outcomes. This is critical for informing treatment decisions and refining the planning of interventional trials. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Geographic AtrophyMacular DegenerationQuality of LifeTomography, Optical CoherenceVisual AcuityAgedAged, 80 and overFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesAge-related macular degenerationGeographic atrophyPatient-reported outcomesQuality of lifeVision-related quality of life

Identifiers

PMID38311207
PMCPMC12872259
OpenAlexW4391513973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.