Evidence map›Paper›PMID 38311164›Full record

ArticleDevelopmental biology2024

Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands.

Xin Gao, Taro Mukaibo, Xiaolu Wei, Roberta C Faustoferri, Maria S Oei, Seo-Kyoung Hwang, Adela Jingyi Yan, James E Melvin, Catherine E Ovitt

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xin GaoSecretory Mechanisms and Dysfunctions Section, National Institutes of Health, Bethesda, MD, 20892, USA.
Taro MukaiboSecretory Mechanisms and Dysfunctions Section, National Institutes of Health, Bethesda, MD, 20892, USA.
Xiaolu WeiCenter for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Roberta C FaustoferriCenter for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Maria S OeiSecretory Mechanisms and Dysfunctions Section, National Institutes of Health, Bethesda, MD, 20892, USA.
Seo-Kyoung HwangCenter for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Adela Jingyi YanCenter for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
James E MelvinSecretory Mechanisms and Dysfunctions Section, National Institutes of Health, Bethesda, MD, 20892, USA.
Catherine E OvittCenter for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA; Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA. Electronic address: catherine_ovitt@urmc.rochester.edu.
University of Rochester · USNational Institutes of Health · US

Funding

NIDCR DIR Secretory Mechanisms and Dysfunctions SectionZIADE000738 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MELVIN, JAMES · 2011 to 2019
$14.4M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
PHYSIOLOGY OF MUCUS-SECRETING SALIVARY GLANDSR01DE008921 · NIDCR · UNIVERSITY OF ROCHESTER · PI OVITT, CATHERINE · 1989 to 2013
$2.9M
Intramural NIH HHS ZIA DE000738Intramural NIH HHS ZIG DE000740NIDCR NIH HHS R01 DE008921
6 · The paper itself

Abstract

Saliva is vital to oral health, fulfilling multiple functions in the oral cavity. Three pairs of major salivary glands and hundreds of minor salivary glands contribute to saliva production. The secretory acinar cells within these glands include two distinct populations. Serous acinar cells secrete a watery saliva containing enzymes, while mucous acinar cells secrete a more viscous fluid containing highly glycosylated mucins. Despite their shared developmental origins, the parotid gland (PG) is comprised of only serous acinar cells, while the sublingual gland (SLG) contains predominantly mucous acinar cells. The instructive signals that govern the identity of serous versus mucous acinar cell phenotypes are not yet known. The homeobox transcription factor Nkx2.3 is uniquely expressed in the SLG. Disruption of the Nkx2.3 gene was reported to delay the maturation of SLG mucous acinar cells. To examine whether Nkx2.3 plays a role in directing the mucous cell phenotype, we analyzed SLG from Nkx2.3-/- mice using RNAseq, immunostaining and proteomic analysis of saliva. Our results indicate that Nkx2.3, most likely in concert with other transcription factors uniquely expressed in the SLG, is a key regulator of the molecular program that specifies the identity of mucous acinar cells.

Indexed as

ProteomicsTranscription FactorsAnimalsHomeodomain ProteinsMiceParotid GlandSalivary GlandsSublingual GlandHomeodomain ProteinsNkx2.3 protein, mouseTranscription FactorsAcinar cellsMucous cellNkx2.3Sublingual salivary glandTranscription factor

Identifiers

PMID38311164
PMCPMC10939741
OpenAlexW4391484505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.