Evidence map›Paper›PMID 38311107›Full record

ArticleOsteoarthritis and cartilage2024

Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort.

Timothy E McAlindon, Jennifer L Hunnicutt, Mary B Roberts, Ida K Haugen, Lena F Schaefer, Jeffrey B Driban, Bing Lu, Jeffrey Duryea, Stacy E Smith, Sarah L Booth and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  10. Ferroptosis in Osteoarthritis: Current Understanding.Journal of inflammation research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Timothy E McAlindonDivision of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA. Electronic address: tmcalindon@tuftsmedicalcenter.org.
Jennifer L HunnicuttSchool of Medicine, Tufts University, Boston, MA, USA. Electronic address: jenny@drhunnicutt.com.
Mary B RobertsCare New England Medical Group/Primary Care and Specialty Services, Pawtucket, RI, USA. Electronic address: mary_roberts@brown.edu.
Ida K HaugenCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway. Electronic address: ida.k.haugen@gmail.com.
Lena F SchaeferDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: lenafranziskaschaefer@yahoo.com.
Jeffrey B DribanDivision of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA. Electronic address: jdriban@gmail.com.
Bing LuUConn Health, University of Connecticut, Farmington, CT, USA. Electronic address: blu@uchc.edu.
Jeffrey DuryeaDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jduryea@bwh.harvard.edu.
Stacy E SmithDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: ssmith@bwh.harvard.edu.
Sarah L BoothJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. Electronic address: sarah.booth@tufts.edu.
Gayle A PettyJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. Electronic address: gayle.petty@tufts.edu.
Alexander MathiessenDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: alexander_mathiessen@hotmail.com.
Li ZengDepartment of Integrative Physiology and Pathobiology, School of Medicine, Tufts University, Boston, MA, USA. Electronic address: li.zeng@tufts.edu.
Charles EatonCare New England Medical Group/Primary Care and Specialty Services, Pawtucket, RI, USA. Electronic address: cbeaton51@gmail.com.
Brigham and Women's Hospital · USTufts University · USTufts Medical Center · USCare International · CHDiakonhjemmet Hospital · NOPrimary Health Care · QAUConn Health · US

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVEN01AR22258 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL · 2007 to 2011
$13.5M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22259 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 2007 to 2011
$7.8M
Clinical Centers for the Osteoarthritis Initiative^Rhode IslandN01AR22262 · NIAMS · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B. · 2007 to 2010
$6.8M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH FDN · PI JACKSON, REBECCA · 2007 to 2011
$6.2M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22260 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2007 to 2010
$6.1M
Constitutional and metabolic factors associated with the development of Hand OAR01AR066378 · NIAMS · TUFTS MEDICAL CENTER · PI MCALINDON, TIMOTHY E · 2015 to 2018
$2.6M
Metabolites of Dietary Intake and Risk of Knee OsteoarthritisR01AR074447 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LU, BING · 2019 to 2022
$2.6M
NHLBI NIH HHS N01AR22258NIAMS NIH HHS N01AR22259NIAMS NIH HHS N01AR22260NIAMS NIH HHS N01AR22261NIAMS NIH HHS N01AR22262NIAMS NIH HHS R01 AR066378NIAMS NIH HHS R01 AR074447
6 · The paper itself

Abstract

objectiveErosive hand osteoarthritis (eHOA) is a subtype of hand osteoarthritis (OA) that develops in finger joints with pre-existing OA and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes.

methodThis was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at baseline and 48-months, and biospecimens collected at baseline. We classified incident radiographic eHOA in individuals with ≥1 joint with Kellgren-Lawrence ≥2 and a central erosion present at 48-months but not at baseline. We used a random representative sample (n = 1282) for comparison. We measured serum biomarkers of inflammation, insulin resistance and dysglycemia, and adipokines using immunoassays and enzymatic colorimetric procedures, blinded to case status.

resultsEighty-six participants developed incident radiographic eHOA. In the multivariate analyses adjusted for age, gender, race, smoking, and body mass index, and after adjustment for multiple analyses, incident radiographic eHOA was associated with elevated levels of interleukin-7 (risk ratio (RR) per SD = 1.30 [95% confidence interval (CI) 1.09, 1.55] p trend 0.01).

conclusionThis exploratory study suggests an association of elevated interleukin-7, an inflammatory cytokine, with incident eHOA, while other cytokines or biomarkers of metabolic inflammation were not associated. Interleukin-7 may mediate inflammation and tissue damage in susceptible osteoarthritic finger joints and participate in erosive progression.

Indexed as

Hand JointsOsteoarthritisBiomarkersHumansInflammationInterleukin-7BiomarkersInterleukin-7BiomarkersCytokinesErosive hand osteoarthritisHand osteoarthritis

Identifiers

PMID38311107
PMCPMC11031286
OpenAlexW4391512906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.