Evidence map›Paper›PMID 38311065›Full record

Trial reportThe Journal of nutrition2024

True Ileal Amino Acid Digestibility and Protein Quality of

Suvi T Itkonen, Juliane Calvez, Gheorghe Airinei, Martin Chapelais, Nadezda Khodorova, Moulay Sahaka, Robert Benamouzig, Frederick L Stoddard, Asko Simojoki, Anne-Maria Pajari and 1 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05047757 (Fava Bean Protein and Amino Acid Bioavailability in Healthy Volunteers), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05047757 nacompletednot on this map

Fava Bean Protein and Amino Acid Bioavailability in Healthy Volunteers

TypeinterventionalSponsorInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementRan2021 to 2023Enrolled17ConditionsIleal Digestibility of Amino AcidsArmsTest meal with 15N labeled favabean
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Current research in food science · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Suvi T ItkonenUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland. Electronic address: suvi.itkonen@helsinki.fi.
Juliane CalvezUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Gheorghe AirineiUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Martin ChapelaisUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Nadezda KhodorovaUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Moulay SahakaUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Robert BenamouzigUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
Frederick L StoddardDepartment of Agricultural Sciences, University of Helsinki, Helsinki, Finland.
Asko SimojokiDepartment of Agricultural Sciences, University of Helsinki, Helsinki, Finland.
Anne-Maria PajariDepartment of Food and Nutrition, University of Helsinki, Helsinki, Finland.
Claire GaudichonUniversité Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
AgroParisTech · FRUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recommended transition toward more plant-based diets, particularly containing legumes, requires a wider knowledge of plant protein bioavailability. Faba beans are cultivated at different latitudes and are used increasingly in human nutrition.

objectivesWe aimed to assess the nutritional quality of faba bean protein in healthy volunteers equipped with an intestinal tube to implement the ileal

methodsNine volunteers completed the study (7 males, 2 females, aged 33 ± 10 y, BMI: 24.7 ± 2.6 kg/m

resultsThe ileal N digestibility was 84.1% ± 7.7%. Postprandial deamination represented 19.2% ± 3.6% of ingested N, and the NPPU was 64.7% ± 9.7%. The ileal digestibility of individual AAs varied from 85.1% ± 13.7% for histidine to 94.2% ± 3.6% for glutamine + glutamate. The mean AA digestibility was ∼6 percentage points higher than the digestibility of N, reaching 89.8% ± 5.9%, whereas indispensable AA digestibility was 88.0% ± 7.3%. Histidine and tryptophan were the first limiting AAs [DIAAS = 0.77 (calculated by legume-specific N-to-protein conversion factor 5.4); 0.67 (by default factor 6.25)]. Sulfur AAs were limiting to a lesser extent [DIAA ratio = 0.94 (N × 5.4); 0.81 (N × 6.25)].

conclusionsProtein ileal digestibility of cooked, dehulled faba beans in humans was moderate (<85%), but that of AAs was close to 90%. Overall protein quality was restricted by the limited histidine and tryptophan content. This trial was registered at clinicaltrials.gov as NCT05047757.

Indexed as

FabaceaeVicia fabaAmino AcidsAnimal FeedDietDietary ProteinsDigestionFemaleHistidineHumansIleumMaleTryptophanAmino AcidsDietary ProteinsHistidineTryptophan(15)N faba beansDIAAShealthy volunteersintestinal tubesnitrogen retentiontrue ileal digestibility

Identifiers

PMID38311065
PMCPMC11007748
OpenAlexW4391513987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.