Evidence map›Paper›PMID 38310894›Full record

Trial reportThe lancet. Healthy longevity2024

A psychosocial goal-setting and manualised support intervention for independence in dementia (NIDUS-Family) versus goal setting and routine care: a single-masked, phase 3, superiority, randomised controlled trial.

Claudia Cooper, Victoria Vickerstaff, Julie Barber, Rosemary Phillips, Margaret Ogden, Kate Walters, Iain Lang, Penny Rapaport, Vasiliki Orgeta, Kenneth Rockwood and 12 more

Open access · goldAbstract readRandomized Controlled TrialClinical Trial, Phase IIIEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The lancet. Healthy longevity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  6. Co-designed films to reduce care burden in India: The Moving Pictures pilot trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  9. Individual Matching Support in Community Dementia Care: A Reflexive Thematic Analysis of Team Orange in Sapporo City.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 12 institutions in 4 countries.

Claudia CooperCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary University London, London, UK. Electronic address: claudia.cooper@qmul.ac.uk.
Victoria VickerstaffResearch Department of Primary Care and Population Health, University College London, London, UK.
Julie BarberDepartment of Statistical Science, University College London, London, UK.
Rosemary PhillipsResearch Network Volunteer, Alzheimer's Society, London, UK.
Margaret OgdenResearch Network Volunteer, Alzheimer's Society, London, UK.
Kate WaltersResearch Department of Primary Care and Population Health, University College London, London, UK.
Iain LangSt Luke's Campus, University of Exeter, Exeter, UK.
Penny RapaportDivision of Psychiatry, University College London, London, UK.
Vasiliki OrgetaDivision of Psychiatry, University College London, London, UK.
Kenneth RockwoodDivision of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada.
Sara BanksCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary University London, London, UK.
Marina PalomoDivision of Psychiatry, University College London, London, UK.
Laurie T ButlerFaculty of Science and Engineering, Anglia Ruskin University, Chelmsford, UK.
Kathyrn LordCentre for Applied Dementia Studies, University of Bradford, Bradford, UK.
Gill LivingstonDivision of Psychiatry, University College London, London, UK.
Sube BanerjeeFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.
Jill ManthorpeThe Policy Institute at King's, King's College London, London, UK.
Briony DowNational Ageing Research Institute, Melbourne, VIC, Australia.
Juanita HoeGeller Institute of Ageing and Memory, School of Biomedical Sciences, University of West London, London, UK.
Rachael HunterResearch Department of Primary Care and Population Health, University College London, London, UK.
Quincy SamusDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Jessica BudgettCentre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary University London, London, UK.
University College London · GBQueen Mary University of London · GBAlzheimer's Society · GBAnglia Ruskin University · GBDalhousie University · CAJohns Hopkins University · USKing's College London · GBNational Ageing Research Institute · AUUniversity of Bradford · GBUniversity of Exeter · GBUniversity of Nottingham · GBUniversity of West London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough national guidelines recommend that everyone with dementia receives personalised post-diagnostic support, few do. Unlike previous interventions that improved personalised outcomes in people with dementia, the NIDUS-Family intervention is fully manualised and deliverable by trained and supervised, non-clinical facilitators. We aimed to investigate the effectiveness of home-based goal setting plus NIDUS-Family in supporting the attainment of personalised goals set by people with dementia and their carers.

methodsWe did a two-arm, single-masked, multi-site, randomised, clinical trial recruiting patient-carer dyads from community settings. We randomly assigned dyads to either home-based goal setting plus NIDUS-Family or goal setting and routine care (control). Randomisation was blocked and stratified by site (2:1; intervention to control), with allocations assigned via a remote web-based system. NIDUS-Family is tailored to goals set by dyads by selecting modules involving behavioural interventions, carer support, psychoeducation, communication and coping skills, enablement, and environmental adaptations. The intervention involved six to eight video-call or telephone sessions (or in person when COVID-19-related restrictions allowed) over 6 months, then telephone follow-ups every 2-3 months for 6 months. The primary outcome was carer-rated goal attainment scaling (GAS) score at 12 months. Analyses were done by intention to treat. This trial is registered with the ISRCTN registry, ISRCTN11425138.

findingsBetween April 30, 2020, and May 9, 2021, we assessed 1083 potential dyads for eligibility, 781 (72·1%) of whom were excluded. Of 302 eligible dyads, we randomly assigned 98 (32·4%) to the control group and 204 (67·5%) to the intervention group. The mean age of participants with dementia was 79·9 years (SD 8·2), 169 (56%) were women, and 133 (44%) were men. 247 (82%) dyads completed the primary outcome, which favoured the intervention (mean GAS score at 12 months 58·7 [SD 13·0; n=163] vs 49·0 [14·1; n=84]; adjusted difference in means 10·23 [95% CI 5·75-14·71]; p<0·001). 31 (15·2%) participants in the intervention group and 14 (14·3%) in the control group experienced serious adverse events.

interpretationTo our knowledge, NIDUS-Family is the first readily scalable intervention for people with dementia and their family carers that improves attainment of personalised goals. We therefore recommend that it be implemented in health and care services.

fundingUK Alzheimer's Society.

Indexed as

DementiaAgedAged, 80 and overBehavior TherapyCaregiversFemaleGoalsHumansMale

Identifiers

PMID38310894
PMCPMC10834374
OpenAlexW4391545021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.