Evidence map›Paper›PMID 38310736›Full record

Observational studyDiabetes & metabolic syndrome2024

Fasting plasma lactate as a possible early clinical marker for metabolic disease risk.

Nicholas T Broskey, Walter J Pories, Eric J DeMaria, Terry E Jones, Charles J Tanner, Donghai Zheng, Polina M Krassovskaia, Lindsay A Mitchell, Laura E Matarese, Kevin F O'Brien and 3 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetes & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Nicholas T BroskeyDepartments of Kinesiology, East Carolina University, Greenville, NC, USA; Surgery, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA. Electronic address: broskeyn19@ecu.edu.
Walter J PoriesSurgery, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Eric J DeMariaSurgery, East Carolina University, Greenville, NC, USA.
Terry E JonesPhysical Therapy, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Charles J TannerDepartments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Donghai ZhengDepartments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Polina M KrassovskaiaDepartments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Lindsay A MitchellPhysical Therapy, East Carolina University, Greenville, NC, USA.
Laura E MatareseSurgery, East Carolina University, Greenville, NC, USA; Internal Medicine, East Carolina University, Greenville, NC, USA.
Kevin F O'BrienPublic Health, East Carolina University, Greenville, NC, USA.
Ronald N CortrightDepartments of Kinesiology, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; Physiology, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
G Lynis DohmPhysiology, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
Joseph A HoumardDepartments of Kinesiology, East Carolina University, Greenville, NC, USA; Surgery, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.
East Carolina University · US

Funding

Investigating the effects of aerobic and resistance training in vivo on skeletal muscle metabolism in vitro in primary human muscle cells (MoTrMyo)R01DK120322 · NIDDK · ADVENTHEALTH ORLANDO · PI HOUMARD, JOSEPH A, SPARKS, LAUREN MARIE · 2019 to 2024
$3.4M
Metabolic inflexibility is related to elevated muscle anaerobic glycolysisR01DK120296 · NIDDK · EAST CAROLINA UNIVERSITY · PI BROSKEY, NICHOLAS, HOUMARD, JOSEPH A · 2019 to 2023
$2.6M
NIDDK NIH HHS R01 DK120296NIDDK NIH HHS R01 DK120322
6 · The paper itself

Abstract

BACKGROUND AND

aimElevated fasting plasma lactate concentrations are evident in individuals with metabolic diseases. However, it has yet to be determined if these associations exist in a young, healthy population as a possible early marker for metabolic disease risk. The purpose of this study was to determine if indices of the metabolic syndrome are related to plasma lactate concentrations in this population.

methodsFifty (29 ± 7 yr) men (n = 19) and women (n = 31) classified as overweight (26.4 ± 1.8 kg/m

resultsTriglycerides (r = 0.55, p=<0.0001), HOMA-IR (r = 0.53, p=<0.0001), and systolic and diastolic (both, r = 0.36, p = 0.01) blood pressures associated with fasting plasma lactate. No differences in visceral adipose tissue existed between the sexes (p = 0.41); however, the relationship between visceral adipose tissue and lactate existed only in females (r = 0.59, p = 0.02) but not in males (p = 0.53). Fasting lactate and HOMA-IR increased in males (p = 0.01 and p = 0.02, respectively), but not females, following a three-day high-fat diet.

conclusionIndices of the metabolic syndrome associated with fasting plasma lactates in young relatively healthy individuals. Fasting lactate also increased in a sex-specific manner after a three-day high fat diet. Thus, lactate could become a clinical marker for metabolic disease risk.

Indexed as

Insulin ResistanceMetabolic SyndromeAdultBiomarkersFastingFemaleHumansInsulinLactic AcidMaleObesityYoung AdultBiomarkersInsulinLactic AcidClinical markerDiabetes riskInsulin resistanceLactateMetabolic syndrome

Identifiers

PMID38310736
PMCPMC10997452
OpenAlexW4391310779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.