Evidence map›Paper›PMID 38310624›Full record

ArticleBiotechnology letters2024

Production of bilirubin via whole-cell transformation utilizing recombinant Corynebacterium glutamicum expressing a β-glucuronidase from Staphylococcus sp. RLH1.

Wei Zhou, Yanan Cui, Mengyun Chen, Qijun Gao, Kai Bao, Yongzhong Wang, Min Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Biotechnology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wei ZhouSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China. weizhou99@ahu.edu.cn.ORCID http://orcid.org/0000-0001-7540-2459
Yanan CuiSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China.
Mengyun ChenSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China.
Qijun GaoSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China.
Kai BaoSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China.
Yongzhong WangSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China.
Min ZhangSchool of Life Sciences, Anhui University, Hefei, 230601, Anhui, China.
Anhui University · CN

Funding

Key Research Program of the Education Department of Anhui Province K120438044Research funding of Anhui university S020318003/012
6 · The paper itself

Abstract

Bilirubin, a key active ingredient of bezoars with extensive clinical applications in China, is produced through a chemical process. However, this method suffers from inefficiency and adverse environmental impacts. To address this challenge, we present a novel and efficient approach for bilirubin production via whole-cell transformation. In this study, we employed Corynebacterium glutamicum ATCC13032 to express a β-glucuronidase (StGUS), an enzyme from Staphylococcus sp. RLH1 that effectively hydrolyzes conjugated bilirubin to bilirubin. Following the optimization of the biotransformation conditions, a remarkable conversion rate of 79.7% in the generation of bilirubin was obtained at temperate 40 °C, pH 7.0, 1 mM Mg

Indexed as

BilirubinCorynebacterium glutamicumChinaGlucuronidaseStaphylococcusBilirubinGlucuronidaseBilirubin productionCorynebacterium glutamicumWhole-cell transformationβ-glucuronidase

Identifiers

PMID38310624
OpenAlexW4391520567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.