Evidence map›Paper›PMID 38310500›Full record

ArticleCytotherapy2024

US state laws on medical freedom and investigational stem cell procedures: a call to focus on state-based legislation.

Kirstin R W Matthews, Samantha J Lowe, Zubin Master

Abstract read
In one paragraph

Article in Cytotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Challenges in the Patent and Legal Environment for Cell Therapies.Advances in experimental medicine and biology · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kirstin R W MatthewsBaker Institute Center for Health and Biosciences, Rice University, Houston, Texas, USA. Electronic address: krwm@rice.edu.
Samantha J LoweBaker Institute Center for Health and Biosciences, Rice University, Houston, Texas, USA.
Zubin MasterBaker Institute Center for Health and Biosciences, Rice University, Houston, Texas, USA; Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: zubin@zubsplace.com.

Funding

Designing Effective Health Education for Patients Seeking Unregulated Stem Cell InterventionsR21AG068620 · NIA · MAYO CLINIC ROCHESTER · PI MASTER, ZUBIN · 2021 to 2022
$437k
Creation of the Novel Interventions Caution (NIC) Measure to Assess Patient Behavior Towards Unregulated Stem Cell InterventionsR03AG078555 · NIA · MAYO CLINIC ROCHESTER · PI LEE, MINJI K, MASTER, ZUBIN · 2022 to 2023
$159k
NIA NIH HHS R03 AG078555NIA NIH HHS R21 AG068620
6 · The paper itself

Abstract

The premature marketing of investigational stem cell interventions (SCIs) is a growing market in the US. Several US states have passed legislation to permit and promote unproven and experimental SCIs for individuals with terminal or chronic diseases. These SCI medical freedom laws, which are largely based on right-to-try legislation, increase access to experimental SCIs with little to no oversight. They undermine federal regulatory authority and can compromise patient safety and informed decision-making. SCI medical freedom laws have gone largely unnoticed by scientific societies interested in the responsible translation of stem cell medicine. In this article, we analyze state SCI medical freedom laws and describe their detrimental impact on patients and society. We contend that scientific and medical societies are uniquely poised to advocate against state-based policy promoting unproven SCIs but recognize resource and other constraints to advocate for or against legislation in 50 states. We recommend societies establish coalitions and share resources to address state-based SCI medical freedom laws and other legislation surrounding unproven SCIs.

Indexed as

Patient SafetyStem CellsFreedomHumansUnited Statescell therapycompassionate usemedical freedomregenerative medicineright-to-trystate policy

Identifiers

PMID38310500
PMCPMC11010147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.