Evidence map›Paper›PMID 38310456›Full record

ReviewCurrent gene therapy2024

CRISPR-Based Therapies: Revolutionizing Drug Development and Precision Medicine.

Dilip Kumar Chanchal, Jitendra Singh Chaudhary, Pushpendra Kumar, Neha Agnihotri, Prateek Porwal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gene therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dilip Kumar ChanchalDepartment of Pharmacy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India.
Jitendra Singh ChaudharyDepartment of Pharmacy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India.ORCID 0009-0003-1160-669X
Pushpendra KumarFaculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah 206130, Uttar Pradesh, India.ORCID 0000-0002-4888-0786
Neha AgnihotriDepartment of Pharmacy, Maharana Pratap College of Pharmacy, Kothi, Mandhana, Kanpur-209217, Uttar Pradesh, India.ORCID 0009-0002-8098-5606
Prateek PorwalGlocal School of Pharmacy, Glocal University Mirzapur Pole, Saharanpur - 247121, Uttar Pradesh, India.ORCID 0000-0001-8240-9878

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the discovery of CRISPR-Cas9, drug development and precision medicine have undergone a major change. This review article looks at the new ways that CRISPR-based therapies are being used and how they are changing the way medicine is done. CRISPR technology's ability to precisely and flexibly edit genes has opened up new ways to find, validate, and develop drug targets. Also, it has made way for personalized gene therapies, precise gene editing, and advanced screening techniques, all of which hold great promise for treating a wide range of diseases. In this article, we look at the latest research and clinical trials that show how CRISPR could be used to treat genetic diseases, cancer, infectious diseases, and other hard-to-treat conditions. However, ethical issues and problems with regulations are also discussed in relation to CRISPR-based therapies, which shows how important it is to use them safely and responsibly. As CRISPR continues to change how drugs are made and used, this review shines a light on the amazing things that have been done and what the future might hold in this rapidly changing field.

Indexed as

CRISPR-Cas SystemsDrug DevelopmentPrecision MedicineClustered Regularly Interspaced Short Palindromic RepeatsGene EditingGenetic TherapyHumansNeoplasmscancer therapy.CRISPR-Cas9drug target identificationgene editinggene therapygenetic disordersprecision medicinescreening techniques

Identifiers

PMID38310456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.