Evidence map›Paper›PMID 38310284›Full record

ArticleBMC veterinary research2024

Intrauterine devices influence prostaglandin secretion by equine uterus: in vitro and in vivo studies.

Katarzyna Karolina Piotrowska-Tomala, Agnieszka Walentyna Jonczyk, Anna Szóstek-Mioduchowska, Takuo Hojo, Ewelina Żebrowska, Terttu Katila, Graca Ferreira-Dias, Dariusz Jan Skarzynski

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In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Katarzyna Karolina Piotrowska-TomalaDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 St., 10-747, Olsztyn, Poland.
Agnieszka Walentyna JonczykDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 St., 10-747, Olsztyn, Poland.
Anna Szóstek-MioduchowskaDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 St., 10-747, Olsztyn, Poland.
Takuo HojoDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 St., 10-747, Olsztyn, Poland.
Ewelina ŻebrowskaDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 St., 10-747, Olsztyn, Poland.
Terttu KatilaDepartment of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, 04920, Saarentaus, Finland.
Graca Ferreira-DiasFaculty of Veterinary Medicine, CIISA-Centre for Interdisciplinary Research in Animal Health, University of Lisbon, 1300-477, Lisbon, Portugal.
Dariusz Jan SkarzynskiDepartment of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10 St., 10-747, Olsztyn, Poland. d.skarzynski@pan.olsztyn.pl.
Institute of Animal Reproduction and Food Research · PLKyushu Okinawa Agricultural Research Center · JPUniversity of Helsinki · FIUniversity of Lisbon · PT

Funding

National Science Center in Poland 2011/02/A/NZ5/00338
6 · The paper itself

Abstract

backgroundIntrauterine devices (IUD) are used in the veterinary practice as the non-pharmacological method of oestrus suppression in mares. When placed in the uterus, IUD create a physical contact with the endometrium that mimics the presence of an equine embryo. However, the mechanism of their action has not been fully elucidated. The objective of the present study was to examine the effect of mechanical stimulation of IUD on mare`s endometrium in both in vitro and in vivo study. For this purpose, we demonstrated the effect of IUD on prostaglandin (PG) F

resultsWe showed for the first time that the incubation of the endometrial cells with the presence of IUD altered the pattern of PG synthase mRNA transcription in equine epithelial and stromal endometrial cells. In vivo, in mares placement with IUD on day 0, PGE

conclusionWe conclude that the application of IUD may mimic the equine conceptus presence through the physical contact with the endometrium altering PG synthase transcription, and act as a potent modulator of endometrial PG secretion both in vitro and in vivo.

Indexed as

DinoprostoneIntrauterine DevicesAnimalsEndometriumFemaleHorsesProstaglandin-Endoperoxide SynthasesProstaglandins FRNA, MessengerDinoprostoneProstaglandin-Endoperoxide SynthasesProstaglandins FRNA, MessengerEndometrial cellsHorseProstaglandin E2Prostaglandin F2αProstaglandin synthases

Identifiers

PMID38310284
PMCPMC10837974
OpenAlexW4391514315

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.