Evidence map›Paper›PMID 38310257›Full record

ArticleJournal of neuroinflammation2024

Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury.

Erwin K Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J Pridham, Michelle L Olsen, Michelle H Theus

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Single-cell RNA sequencing in stroke and traumatic brain injury: Current achievements, challenges and future perspectives on transcriptomic profiling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erwin K Gudenschwager BassoDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, 970 Washington Street SW, Life Sciences I, Rm 249 (MC0910), Blacksburg, VA, 24061, USA.
Jing JuDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, 970 Washington Street SW, Life Sciences I, Rm 249 (MC0910), Blacksburg, VA, 24061, USA.
Eman SolimanDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, 970 Washington Street SW, Life Sciences I, Rm 249 (MC0910), Blacksburg, VA, 24061, USA.
Caroline de JagerTranslational, Biology, Medicine and Health Graduate Program, Virginia Tech, Roanoke, VA, 24016, USA.
Xiaoran WeiSchool of Neuroscience, Virginia Tech, Blacksburg, VA, 24061, USA.
Kevin J PridhamDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, 970 Washington Street SW, Life Sciences I, Rm 249 (MC0910), Blacksburg, VA, 24061, USA.
Michelle L OlsenSchool of Neuroscience, Virginia Tech, Blacksburg, VA, 24061, USA.
Michelle H TheusDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, 970 Washington Street SW, Life Sciences I, Rm 249 (MC0910), Blacksburg, VA, 24061, USA. mtheus@vt.edu.
Virginia Tech · USUniversity of Florida · US

Funding

Divergent age-dependent peripheral innate immune response following TBIR01NS119540 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI THEUS, MICHELLE LEE · 2021 to 2025
$2.6M
Novel mechanisms suppressing the pro-resolving phenotype of peripheral innate immunity following traumatic brain injuryR01NS121103 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI THEUS, MICHELLE LEE · 2021 to 2025
$2.5M
Mechanisms Regulating Cerebral Arteriogenesis and NeurorestorationR01NS096281 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI THEUS, MICHELLE LEE · 2016 to 2020
$1.9M
NINDS NIH HHS NS096281NINDS NIH HHS R01 NS096281NINDS NIH HHS R01 NS119540NINDS NIH HHS R01 NS121103
6 · The paper itself

Abstract

Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals that trauma induces the augmented release of a transcriptionally distinct CD115

Indexed as

Brain InjuriesMonocytesAnimalsBrainCathepsin GGene Expression ProfilingMiceNeutrophilsCathepsin GCtsg protein, mouseClodronateInnate immunityNeuroinflammationTraumatic brain injury

Identifiers

PMID38310257
PMCPMC10838447
OpenAlexW4391509820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.