Trial reportBMC oral health2024
Efficacy of flossing and mouth rinsing regimens on plaque and gingivitis: a randomized clinical trial.
Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05600231 (Twelve Week Clinical Efficacy of Virtually Supervised Mouth Rinse and Flossing), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Twelve Week Clinical Efficacy of Virtually Supervised Mouth Rinse and Flossing: Effect on Plaque, Gingivitis, and Microbiome
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Essential oils mouthwash with or without alcohol in relation to effect on parameters of plaque and gingivitis: A systematic review and meta-analysis.International journal of dental hygiene · 2025Pooled it
- Quantitative analysis of the effects of brushing, flossing, and mouthrinsing on supragingival and subgingival plaque microbiota: 12-week clinical trial.BMC oral health · 2024Trial
- Association between dental flossing frequency and oral microbiome in U.S. adults.Annals of medicine · 2026Article
- Association of Subjective Oral Status and Oral Health Behaviours With a History of Systemic Disease Among Community-Dwelling Older Adults.Oral health & preventive dentistry · 2026Article
- Dental Caries in Older Adults: A Narrative Review for Non-Dental Providers.International journal of environmental research and public health · 2026Review
- Article
- Association and predictive value of C-reactive protein, fibrinogen and periodontal indices in periodontitis severity : a cross-sectional study.Clinical oral investigations · 2026Article
- Knowledge, attitudes and oral health care practices of children in Tshwane District, South Africa.BMC oral health · 2026Article
- Predicting plaque-gingivitis risk in schoolchildren using an interpretable machine learning model: a cross-sectional study.BMC oral health · 2025Article
- Antibacterial and Antibiofilm Activity of TheraBreath™ Oral Rinses: An In Vitro Study.Dentistry journal · 2025Article
- The Impact of Oral Health and Dental Care on Pregnancy: A Cross-Sectional Study Among Women of Reproductive Age.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the effects of combinations of mechanical (brushing and flossing) and chemotherapeutic regimens which included essential oils (EO) non-alcohol and alcohol-containing mouthrinses compared to brushing only in the prevention and reduction of plaque, gingivitis, and gingival bleeding.
methodsThis was a randomized, virtually supervised, examiner blind, controlled clinical trial. Following informed consent and screening, subjects (N = 270) with gingivitis were randomly assigned to one of the following regimens: (1) Brush Only (B, n = 54); (2) Brush/Rinse (EO alcohol-containing mouthrinse) (BA, n = 54); (3) Brush/Rinse (EO non-alcohol containing mouthrinse) (BZ, n = 54); (4) Brush/Floss (BF, n = 54); (5) Brush/Floss/Rinse (EO non-alcohol containing mouthrinse) (BFZ, n = 54). Unflavored waxed dental floss (REACH unflavored waxed dental floss), and fluoridated toothpaste (Colgate Cavity Protection) were used. Examinations included oral hard and soft tissue, plaque, gingivitis, gingival bleeding, probing depth and bleeding on probing.
resultsAfter 12 weeks, both BA and BZ and the BFZ group were superior in reducing interproximal plaque (30.8%, 18.2%, 16.0%, respectively), gingivitis (39.0%, 36.9%, 36.1%, respectively), and bleeding (67.8%, 73.6%, 79.8%, respectively) compared to B. The BF group did not provide significant reductions in interproximal plaque but did reduce interproximal gingivitis (5.1%, p = 0.041) at Week 4 and bleeding at Weeks 4 and 12 (34.6%, 31.4%, p < 0.001 respectively) compared to B. The BFZ group did not significantly reduce interproximal plaque, gingivitis or bleeding compared to BZ.
conclusionsThis study demonstrated that the addition of EO non-alcohol containing mouthrinse to the manual toothbrushing and flossing regimen further reduces plaque, gingivitis and bleeding showing that addition of EO mouthrinses (alcohol or non-alcohol containing) to the oral hygiene regimen provides sustained reductions in plaque to help maintain gingival health after a dental prophylaxis. Dental professional recommendation of the addition of an EO non-alcohol containing mouthrinse to daily oral hygiene routines of brushing or brushing and flossing should be considered to aid supragingival plaque control and improve gingivitis prevention. STUDY REGISTRY NUMBER: NCT05600231.
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