Evidence map›Paper›PMID 38310231›Full record

ArticleBMC veterinary research2024

Diagnostic benefits of platelet-to-lymphocyte, neutrophil-to-lymphocyte, and albumin-to-globulin ratios in dogs with nasal cavity diseases.

Sarah Rösch, Julia Woitas, Stephan Neumann, Michaele Alef, Ingmar Kiefer, Gerhard Oechtering

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Reference Intervals for Hematological Inflammatory Ratios in Healthy Dogs.Animals : an open access journal from MDPI · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sarah RöschSmall Animal Department, ENT-Unit, University of Leipzig, An den Tierkliniken 23, Leipzig, SN, DE- 04103, Germany. sarah.roesch@tiho-hannover.de.
Julia WoitasSmall Animal Department, ENT-Unit, University of Leipzig, An den Tierkliniken 23, Leipzig, SN, DE- 04103, Germany.
Stephan NeumannInstitute of Veterinary Medicine, University of Goettingen, Burckhardtweg 2, Goettingen, NI, DE-37077, Germany.
Michaele AlefSmall Animal Department, University of Leipzig, An den Tierkliniken 23, Leipzig, SN, DE-04103, Germany.
Ingmar KieferSmall Animal Department, University of Leipzig, An den Tierkliniken 23, Leipzig, SN, DE-04103, Germany.
Gerhard OechteringSmall Animal Department, ENT-Unit, University of Leipzig, An den Tierkliniken 23, Leipzig, SN, DE- 04103, Germany. oechtering@kleintierklinik.uni-leipzig.de.
Leipzig University · DEUniversity of Göttingen · DEUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA multimodal approach for diagnostic tests under anesthesia is required to diagnose nasal cavity pathology (NP) reliably in dogs. Blood test results may provide clues to the suspected NP.

methodsThis prospective blinded study assessed 72 dogs with chronic nasal discharge due to NPs, and 10 healthy dogs as the control group (CG). NPs were diagnosed using whole-body computed tomography (CT), upper airway endoscopy, examination of nasal mucosal swabs by bacterial and fungal culture, and histopathological examination of nasal mucosa biopsies. The exclusion criteria were the presence of any additional diseases or corticosteroid pre-treatment. In consideration of these exclusion criteria, 55 dogs entered the study. Dogs were classified into benign (benign tumors, idiopathic rhinitis (IR), and others) and malignant (carcinomas and sarcomas) NP groups. Blood count and blood chemistry tests were performed. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and albumin-to-globulin ratio (AGR) were calculated and compared.

results25 dogs with malignant NP (13 and 12 with carcinomas and sarcomas, respectively) and 30 dogs with benign NP (seven with benign tumors,13 with IR, and 10 others) were included. In general, in dogs with NP there were only slight abnormalities in complete blood count. However, PLR was significantly higher in dogs with malignant NP (carcinoma and sarcoma) than in those with benign NP and in the CG. Compared with the CG, the NLR was significantly increased in all dogs with NP, and the AGR was mild but significantly lower, except in dogs with sarcomas and benign tumors.

conclusionsIn dogs with nasal disease alone, there are usually no marked abnormalities in blood count. However, while mildly increased NLR and decreased AGR can be observed in almost all NPs, an increased PLR may indicate a malignant NP and can be used as an additional screening tool in dogs with nasal discharge due to nasal cavity pathology.

Indexed as

CarcinomaDog DiseasesGlobulinsRhinitisSarcomaAlbuminsAnimalsDogsLymphocytesNasal CavityNasal MucosaNeutrophilsProspective StudiesRetrospective StudiesAlbuminsGlobulinsLymphoplasmacytic rhinitisNasal tumorRhinoscopySinonasal aspergillosis

Identifiers

PMID38310231
PMCPMC10837884
OpenAlexW4391512172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.