Evidence map›Paper›PMID 38310167›Full record

ArticleAmino acids2024

D-Amino acids differentially trigger an inflammatory environment in vitro.

Siew Hwei Yap, Cheng Siang Lee, Nur Diyana Zulkifli, Darshinie Suresh, Kenji Hamase, Kumitaa Theva Das, Reena Rajasuriar, Kok Hoong Leong

Open access · goldAbstract read
In one paragraph

Article in Amino acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Nutrients · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Effects of fasting and inflammatory challenges on the swine hepatic metabolome.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2025
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Siew Hwei YapCentre of Excellence for Research in AIDS (CERiA), Universiti Malaya, Kuala Lumpur, Malaysia.
Cheng Siang LeeCentre of Excellence for Research in AIDS (CERiA), Universiti Malaya, Kuala Lumpur, Malaysia.
Nur Diyana ZulkifliDepartment of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia.
Darshinie SureshDepartment of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia.
Kenji HamaseGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Kumitaa Theva DasDepartment of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia.
Reena RajasuriarCentre of Excellence for Research in AIDS (CERiA), Universiti Malaya, Kuala Lumpur, Malaysia.
Kok Hoong LeongDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, Malaysia. leongkh@um.edu.my.
University of Malaya · MYUniversiti Sains Malaysia · MYKyushu University · JPNational University of Malaysia · MYPeter Doherty Institute · AU

Funding

Agilent Technologies, Inc PV018-2017Fundamental Research Grant Scheme FRGS/1/2019/SKK08/UM/02/7International Centre for Genetic Engineering and Biotechnology CRP/MYS17-05
6 · The paper itself

Abstract

Studies in vivo have demonstrated that the accumulation of D-amino acids (D-AAs) is associated with age-related diseases and increased immune activation. However, the underlying mechanism(s) of these observations are not well defined. The metabolism of D-AAs by D-amino oxidase (DAO) produces hydrogen peroxide (H

Indexed as

Amino AcidsNF-kappa BCytokinesHumansHydrogen PeroxideInterleukin-8Tumor Necrosis Factor-alphaAmino AcidsCytokinesHydrogen PeroxideInterleukin-8NF-kappa BTumor Necrosis Factor-alphaD-AlanineD-Amino acid oxidaseD-SerineInflammationTNF-α

Identifiers

PMID38310167
PMCPMC10838247
OpenAlexW4391508471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.