ArticleNature communications2024
Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Spiral scan and cylindrical deconvolution to maximize image volume and contrast of multiphoton GRIN microendoscopy.Biomedical optics express · 2026Article
- Miniature 3D-printed rod-like refractive objective for endoscopic applications.Journal of biomedical optics · 2026Article
- Spectral-acoustic-coordinated astigmatic metalens for wide field-of-view and high spatiotemporal resolution 3D imaging.Light, science & applications · 2026Article
- Large field-of-view volumetric deep brain imaging through gradient-index lenses.Nature communications · 2025Article
- Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.ACS photonics · 2025Review
- Article
- FLIMB: fluorescence lifetime microendoscopy for metabolic and functional imaging of femoral marrow at subcellular resolution.Biomedical optics express · 2025Article
- Imaging Single-Cell CaBio-protocol · 2024Article
- Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses.Nature communications · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
The advance of genetic function indicators has enabled the observation of neuronal activities at single-cell resolutions. A major challenge for the applications on mammalian brains is the limited optical access depth. Currently, the method of choice to access deep brain structures is to insert miniature optical components. Among these validated miniature optics, the gradient-index (GRIN) lens has been widely employed for its compactness and simplicity. However, due to strong fourth-order astigmatism, GRIN lenses suffer from a small imaging field of view, which severely limits the measurement throughput and success rate. To overcome these challenges, we developed geometric transformation adaptive optics (GTAO), which enables adaptable achromatic large-volume correction through GRIN lenses. We demonstrate its major advances through in vivo structural and functional imaging of mouse brains. The results suggest that GTAO can serve as a versatile solution to enable large-volume recording of deep brain structures and activities through GRIN lenses.
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Registered trials
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