ArticleThe Plant cell2024
CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- JrCDPK13L-mediated phosphorylation of JrERF113L promotes walnut resistance to Colletotrichum gloeosporioides.Plant physiology · 2026Article
- Baiting blast fungi: an engineered NLR domain improves effector recognition.The Plant cell · 2026Article
- A sequential MAP kinase cascade regulates mechanical signalling.Nature communications · 2026Article
- Article
- Overexpression of EXO70E2 inGenes · 2026Article
- Calcium signaling in crops.The New phytologist · 2026Review
- Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026Review
- Loss of calcium-dependent protein kinases OsCPK5 and OsCPK13 leads to NLR-dependent resistance in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The important role of chloroplasts in plant immunity.Plant communications · 2025Review
- The complex immune puzzle: A deeper dive into the MORC1-mediated broad-spectrum defense signaling pathway.The Plant cell · 2025Article
- Functional Characterization of Pomegranate CAMTA3 in Cold Stress Responses.Plants (Basel, Switzerland) · 2025Article
- Calmodulin-Binding Transcription Factors: Roles in Plant Response to Abiotic Stresses.Plants (Basel, Switzerland) · 2025Review
- The role of Exo70s in plant defense against pathogens and insect pests and their application for crop breeding.Molecular breeding : new strategies in plant improvement · 2025Review
- Calcium-dependent protein kinases in plant immunity: from calcium signaling to network integration.Frontiers in plant science · 2025Review
- The Vital Role of theInternational journal of molecular sciences · 2024Article
- OsCAMTA3 Negatively Regulates Disease Resistance toInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Calcium-dependent protein kinases (CPKs) can decode and translate intracellular calcium signals to induce plant immunity. Mutation of the exocyst subunit gene EXO70B1 causes autoimmunity that depends on CPK5 and the Toll/interleukin-1 receptor (TIR) domain resistance protein TIR-NBS2 (TN2), where direct interaction with TN2 stabilizes CPK5 kinase activity. However, how the CPK5-TN2 interaction initiates downstream immune responses remains unclear. Here, we show that, besides CPK5 activity, the physical interaction between CPK5 and functional TN2 triggers immune activation in exo70B1 and may represent reciprocal regulation between CPK5 and the TIR domain functions of TN2 in Arabidopsis (Arabidopsis thaliana). Moreover, we detected differential phosphorylation of the calmodulin-binding transcription activator 3 (CAMTA3) in the cpk5 background. CPK5 directly phosphorylates CAMTA3 at S964, contributing to its destabilization. The gain-of-function CAMTA3A855V variant that resists CPK5-induced degradation rescues immunity activated through CPK5 overexpression or exo70B1 mutation. Thus, CPK5-mediated immunity is executed through CAMTA3 repressor degradation via phosphorylation-induced and/or calmodulin-regulated processes. Conversely, autoimmunity in camta3 also partially requires functional CPK5. While the TIR domain activity of TN2 remains to be tested, our study uncovers a TN2-CPK5-CAMTA3 signaling module for exo70B1-mediated autoimmunity, highlighting the direct embedding of a calcium-sensing decoder element within resistance signalosomes.
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