ArticleJournal of advanced research2025
Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice.
Article in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Bioactive Compounds from Edible and Medicinal Mushrooms in Obesity-Depression Comorbidity: Gut-Brain Axis Mechanisms and Functional Food Perspectives.Foods (Basel, Switzerland) · 2026Review
- Ultrasonic Degradation Improves the In Vitro Utilization of Oolong Tea Pectic Polysaccharides: Structure Characterization and Multi-Omics Insights.Foods (Basel, Switzerland) · 2026Article
- Parameter Optimization and Regulatory Mechanism of Cold Plasma Pretreatment for Enhancing Intracellular Polysaccharides Yield in Irpex lacteus.Applied biochemistry and biotechnology · 2026Article
- Deep Eutectic Solvent-Based Extraction Optimization, Structural Characterization, and Alleviating Effects ofFoods (Basel, Switzerland) · 2026Article
- Extraction, Purification, Structural Characterization, Biological Activities and Applications in Food of Polysaccharides fromFoods (Basel, Switzerland) · 2026Review
- Untapped microbial factories for next-generation therapeutics: Endophytic fungi of medicinal plants.Microbial cell factories · 2026Review
- Deciphering the Structure-Immunomodulatory Function Relationships of Homopolysaccharides.Nutrients · 2026Review
- Perfect Partner for a Dietary Alkaloid: Dual Role of Coptis chinensis Polysaccharide in Berberine Taste Masking and Immune Amplification.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Beyond conventional drying: improving the quality of dried Tremella fuciformis via a heat-integrated pretreatment.NPJ science of food · 2026Article
- Effect of Ultrafine Grinding on the Physicochemical Properties ofFoods (Basel, Switzerland) · 2026Article
- 2',4'-dihydroxychalcone alleviates inflammatory bowel disease by inhibiting NLRP3 inflammasome and modulating gut microbiota.Frontiers in immunology · 2026Article
- Antioxidant and Hypoglycemic Activity of Polysaccharides With Different Tissues From Rosa roxburghii f. eseiosa Ku.Chemistry & biodiversity · 2026Article
- Article
- Structural Elucidation of Heteropolysaccharides from the Peach-ShapedFoods (Basel, Switzerland) · 2025Article
- Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice.NPJ science of food · 2025Article
- Article
- Radix Pseudostellaria polysaccharides alleviate sepsis-induced liver injury by modulating the gut microbiota via the TLR4/NF-κB pathway.Frontiers in pharmacology · 2025Article
- Effects of superfine grindingFood chemistry: X · 2024Article
- The Isolation, Structural Characterization and Anti-Inflammatory Potentials of Neutral Polysaccharides from the Roots ofMolecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOver decades, the source-function relationships of bioactive polysaccharides have been progressively investigated, however, it is still unclear how a defined structure may conduce to the bioactivities of polysaccharides.
objectivesTo explore the structure-function relationship of fungus polysaccharides, we employed a dextran sulfate sodium (DSS)-induced colitis mouse model to compare the anti-inflammatory activity of two fungus polysaccharides from Dictyophora indusiata (DIP) and Tremella fuciformis (TFP), which exhibit distinct glycosidic linkages.
methodsThe structures of DIP and TFP were characterized through molecular weight detection, molecular morphology analysis, methylation analysis, and NMR analysis. Subsequently, we employed a DSS-induced colitis model to assess the anti-inflammatory efficacy of DIP and TFP. The colitis symptoms, histological morphology, intestinal inflammatory cytokines, and the composition and function of gut microbiota before and after polysaccharides treatment in colitis mice were also investigated.
resultsDIP, l,3-β-D-glucan with 1,4-β and 1,6-β-D-Glcp as branched chains, exhibited superior therapeutic effect than that of TFP consisted of a linear 1,3-α-D-mannose backbone with D-xylose and L-fucose in the side chains. Both DIP and TFP relieved DSS-induced colitis in a gut microbiota-dependent manner. Furthermore, metagenomics showed that DIP and TFP could partially reverse the bacterial function in colitis mice. Glycoside Hydrolase 1 (GH1) and GH3 were identified as being involved in hydrolyzing the glucose linkages in DIP, while GH92 and GH29 were predicted to be active in cleaving the α-1,3-linked mannose linkages and the glycosidic bonds of L-fucose residues in TFP.
conclusionOur findings highlight the pivotal role of glycosidic linkages in anti-inflammatory activities of fungus polysaccharides and would promote the design and discovery of polysaccharides with designated activity to be used as functional foods and/or therapeutics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.