Evidence map›Paper›PMID 38309495›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2024

Validation of the Laryngeal Cognitive-Affective Tool.

Amanda J Krause, Tiffany Taft, Madeline Greytak, Zoe C Burger, Erin Walsh, Philip Weissbrod, John E Pandolfino, Rena Yadlapati

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Randomized Controlled Trial of Upper Esophageal Sphincter Assist Device in Laryngopharyngeal Reflux Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. The role of hypervigilance in chronic esophageal diseases: a scoping review.Translational gastroenterology and hepatology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amanda J KrauseDivision of Gastroenterology & Hepatology, Department of Medicine, University of California San Diego, La Jolla, California.
Tiffany TaftDivision of Gastroenterology & Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Madeline GreytakDivision of Gastroenterology & Hepatology, Department of Medicine, University of California San Diego, La Jolla, California.
Zoe C BurgerDivision of Gastroenterology & Hepatology, Department of Medicine, University of California San Diego, La Jolla, California.
Erin WalshDepartment of Otolaryngology, University of California San Diego, La Jolla, California.
Philip WeissbrodDepartment of Otolaryngology, University of California San Diego, La Jolla, California.
John E PandolfinoDivision of Gastroenterology & Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Rena YadlapatiDivision of Gastroenterology & Hepatology, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: ryadlapati@ucsd.edu.
University of California San Diego · USNorthwestern University · US

Funding

Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal RefluxR01DK139089 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rena Hiren Yadlapati · 2024 to 2026
$2.0M
Mechanism Guided Therapy for Laryngopharyngeal RefluxK23DK125266 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2021 to 2025
$963k
Role of Psychological Processes on Symptom Burden in Laryngopharyngeal RefluxR03DK135513 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2023 to 2024
$245k
NIDDK NIH HHS K23 DK125266NIDDK NIH HHS R01 DK139089NIDDK NIH HHS R03 DK135513NIDDK NIH HHS T32 DK007202
6 · The paper itself

Abstract

BACKGROUND &

aimsCognitive-affective processes, including hypervigilance and symptom-specific anxiety, may contribute to chronic laryngeal symptoms and are potentially modifiable; however, a validated instrument to assess these constructs is lacking. The aims of this study were to develop and validate the Laryngeal Cognitive-Affective Tool (LCAT) instrument.

methodsThis 2-phase single-center prospective study enrolled participants from November 2021 to June 2023. In the initial phase 1:1 patient cognitive interviews and multidisciplinary team consensus were conducted to develop the LCAT. In the second phase asymptomatic and symptomatic participants completed a series of questionnaires to examine psychometric properties of the LCAT.

resultsA total of 268 participants were included: 8 in the initial phase and 260 in the validation phase (56 asymptomatic; 204 symptomatic). A 15-item LCAT was developed. In the validation phase, mean total LCAT and hypervigilance/anxiety subscores were significantly higher in symptomatic versus asymptomatic participants (P < .01). The LCAT had excellent internal consistency (α = 0.942) and split-half reliability (Guttman = 0.853). Using a median split, a score of 33 or greater was defined as elevated.

conclusionsThe 15-item LCAT evaluates laryngeal hypervigilance and symptom-specific anxiety among patients with laryngeal symptoms. It has excellent reliability and construct validity. The LCAT highlights burdensome cognitive-affective processes that can accordingly help tailor treatments.

Indexed as

PsychometricsAdultAgedAnxietyCognitionFemaleHumansLaryngeal DiseasesMaleMiddle AgedProspective StudiesReproducibility of ResultsSurveys and QuestionnairesGastroesophageal RefluxLaryngopharyngeal RefluxPatient-Reported Outcome MeasuresPsychosocial Functioning

Identifiers

PMID38309495
PMCPMC11193647
OpenAlexW4392180954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.