Evidence map›Paper›PMID 38309480›Full record

ArticleJournal of affective disorders2024

Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk.

Murray B Stein, Sonia Jain, Santiago Papini, Laura Campbell-Sills, Karmel W Choi, Brian Martis, Xiaoying Sun, Feng He, Erin B Ware, James A Naifeh and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 1 country.

Murray B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA. Electronic address: mstein@health.ucsd.edu.
Sonia JainHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Santiago PapiniDepartment of Psychology, University of Hawai'i at Mānoa, Honolulu, HI, USA.
Laura Campbell-SillsDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Karmel W ChoiPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Brian MartisDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA.
Xiaoying SunHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Feng HeHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Erin B WareInstitute for Social Research, University of Michigan, Ann Arbor, MI, USA.
James A NaifehCenter for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Pablo A AliagaCenter for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
for International Suicide Genetics Consortium
for MVP Suicide Exemplar Workgroup
for VA Million Veteran Program
for Suicide Working Group of the Psychiatric Genomics Consortium
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Joel GelernterDepartments of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Robert J UrsanoCenter for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
University of California, San Diego · USMassachusetts General Hospital · USUniformed Services University of the Health Sciences · USVA San Diego Healthcare System · USHarvard University · USHuman Longevity (United States) · USUniversity of Michigan–Ann Arbor · USYale University · US

Funding

Modifiable Risk and Protective Factors for Suicidal Behaviors in the US ArmyU01MH087981 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI STEIN, MURRAY B., URSANO, ROBERT J. · 2009 to 2013
$65.0M
Integrating Health Records, Genomic, and Social Data to Stratify Adolescent Depression RiskK08MH127413 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, KARMEL · 2021 to 2025
$987k
NIMH NIH HHS K08 MH127413NIMH NIH HHS U01 MH087981
6 · The paper itself

Abstract

backgroundSuicide is a leading cause of death worldwide. Whereas some studies have suggested that a direct measure of common genetic liability for suicide attempts (SA), captured by a polygenic risk score for SA (SA-PRS), explains risk independent of parental history, further confirmation would be useful. Even more unsettled is the extent to which SA-PRS is associated with lifetime non-suicidal self-injury (NSSI).

methodsWe used summary statistics from the largest available GWAS study of SA to generate SA-PRS for two non-overlapping cohorts of soldiers of European ancestry. These were tested in multivariable models that included parental major depressive disorder (MDD) and parental SA.

resultsIn the first cohort, 417 (6.3 %) of 6573 soldiers reported lifetime SA and 1195 (18.2 %) reported lifetime NSSI. In a multivariable model that included parental history of MDD and parental history of SA, SA-PRS remained significantly associated with lifetime SA [aOR = 1.26, 95%CI:1.13-1.39, p < 0.001] per standardized unit SA-PRS]. In the second cohort, 204 (4.2 %) of 4900 soldiers reported lifetime SA, and 299 (6.1 %) reported lifetime NSSI. In a multivariable model that included parental history of MDD and parental history of SA, SA-PRS remained significantly associated with lifetime SA [aOR = 1.20, 95%CI:1.04-1.38, p = 0.014]. A combined analysis of both cohorts yielded similar results. In neither cohort or in the combined analysis was SA-PRS significantly associated with NSSI.

conclusionsPRS for SA conveys information about likelihood of lifetime SA (but not NSSI, demonstrating specificity), independent of self-reported parental history of MDD and parental history of SA. LIMITATIONS: At present, the magnitude of effects is small and would not be immediately useful for clinical decision-making or risk-stratified prevention initiatives, but this may be expected to improve with further iterations. Also critical will be the extension of these findings to more diverse populations.

Indexed as

Major Depressive DisorderMilitary PersonnelSelf-Injurious BehaviorHumansParentsRisk FactorsSuicidal IdeationSuicide, AttemptedGeneticsNon-suicidal self-injuryPolygenic riskSuicideSuicide attempt

Identifiers

PMID38309480
PMCPMC11259154
OpenAlexW4391424717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.