Evidence map›Paper›PMID 38309478›Full record

ArticleJournal of affective disorders2024

Genome-wide DNA methylation analysis in female veterans with military sexual trauma and comorbid PTSD/MDD.

Pedro S Marra, Tomoteru Seki, Yoshitaka Nishizawa, Gloria Chang, Kyosuke Yamanishi, Tsuyoshi Nishiguchi, Kazuki Shibata, Patricia Braun, Gen Shinozaki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Pedro S MarraDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; University of California, San Francisco School of Medicine, San Francisco, CA, USA.
Tomoteru SekiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Psychiatry, Tokyo Medical University, Shinjuku, Tokyo, Japan.
Yoshitaka NishizawaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Neuropsychiatry, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Gloria ChangDepartment of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Developmental Psychology Graduate Program, Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Kyosuke YamanishiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Neuropsychiatry, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
Tsuyoshi NishiguchiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
Kazuki ShibataDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Sumitomo Pharma Co. Ltd, Osaka, Osaka, Japan.
Patricia BraunDepartment of Biology, Clarke University, Dubuque, IA, USA.
Gen ShinozakiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: gens@stanford.edu.
Stanford University · USUniversity of Iowa Hospitals and Clinics · USClarke University · USOsaka University of Pharmaceutical Sciences · JPTokyo Medical University · JPTottori University · JP

Funding

Identification of Epigenetics Correlates between Brain and Peripheral TissuesR01MH119165 · NIMH · UNIVERSITY OF IOWA · PI SHINOZAKI, GEN · 2020 to 2024
$3.0M
Epigenetic Investigation of Trauma in PTSD and DepressionK23MH107654 · NIMH · UNIVERSITY OF IOWA · PI SHINOZAKI, GEN · 2015 to 2018
$718k
NIMH NIH HHS K23 MH107654NIMH NIH HHS R01 MH119165
6 · The paper itself

Abstract

backgroundMilitary sexual trauma (MST) is a prevalent issue within the U.S. military. Victims are more likely to develop comorbid diseases such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Nonetheless, not everyone who suffers from MST develops PTSD and/or MDD. DNA methylation, which can regulate gene expression, might give us insight into the molecular mechanisms behind this discrepancy. Therefore, we sought to identify genomic loci and enriched biological pathways that differ between patients with and without MST, PTSD, and MDD.

methodsSaliva samples were collected from 113 female veterans. Following DNA extraction and processing, DNA methylation levels were measured through the Infinium HumanMethylationEPIC BeadChip array. We used limma and bump hunting methods to generate the differentially methylated positions and differentially methylated regions (DMRs), respectively. Concurrently, we used Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome to find enriched pathways.

resultsA DMR close to the transcription start site of ZFP57 was differentially methylated between subjects with and without PTSD, replicating previous findings and emphasizing the potential role of ZFP57 in PTSD susceptibility. In the pathway analyses, none survived multiple correction, although top GO terms included some potentially relevant to MST, PTSD, and MDD etiology.

conclusionWe conducted one of the first DNA methylation analyses investigating MST along with PTSD and MDD. In addition, we found one DMR near ZFP57 to be associated with PTSD. The replication of this finding indicates further investigation of ZFP57 in PTSD may be warranted.

Indexed as

Major Depressive DisorderMilitary PersonnelSex OffensesStress Disorders, Post-TraumaticVeteransDNA MethylationFemaleHumansMilitary Sexual TraumaDNA methylationEpigeneticsMajor depressive disorderMilitary sexual traumaPosttraumatic stress disorder

Identifiers

PMID38309478
PMCPMC11107447
OpenAlexW4391463937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.