Evidence map›Paper›PMID 38309446›Full record

ArticleGenomics2024

Intestinal epithelial adaptations to vertical sleeve gastrectomy defined at single-cell resolution.

Kieran Koch-Laskowski, Ki-Suk Kim, Maigen Bethea, Kelly N Z Fuller, Darleen A Sandoval, Praveen Sethupathy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of the gut-brain axis in bariatric surgery.Current opinion in neurobiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kieran Koch-LaskowskiDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA.
Ki-Suk KimDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Maigen BetheaDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kelly N Z FullerDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Darleen A SandovalDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Praveen SethupathyDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA. Electronic address: pr46@cornell.edu.
University of Colorado Anschutz Medical Campus · USCornell University · USUniversity of Tennessee Health Science Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Mechanisms of Post-Bariatric HypoglycemiaR01DK121995 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATTI, MARY E, SANDOVAL, DARLEEN A. · 2019 to 2022
$2.8M
A novel paracrine role for GLP-1 in the isletR01DK107282 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDOVAL, DARLEEN A. · 2017 to 2020
$1.6M
Cornell University Veterinary Investigator ProgramT35OD010941 · OD · CORNELL UNIVERSITY · PI WEISS, ROBERT S · 2012 to 2024
$813k
The role of enteroendocrine cell differentiation in the success of bariatric surgeryK01DK129367 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KIM, KI SUK · 2021 to 2025
$672k
MicroRNA-375 regulation of enteroendocrine cell biology in diet-induced obesity and bariatric surgeryF30OD031914 · OD · CORNELL UNIVERSITY · PI KOCH-LASKOWSKI, KIERAN LOUISE · 2021 to 2025
$238k
NCI NIH HHS P30 CA046934NIDDK NIH HHS K01 DK129367NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK107282NIDDK NIH HHS R01 DK121995NIH HHS F30 OD031914NIH HHS T35 OD010941
6 · The paper itself

Abstract

The gut plays a key role in regulating metabolic health. Dietary factors disrupt intestinal physiology and contribute to obesity and diabetes, whereas bariatric procedures such as vertical sleeve gastrectomy (VSG) cause gut adaptations that induce robust metabolic improvements. However, our understanding of these adaptations at the cellular and molecular levels remains limited. In a validated murine model, we leverage single-cell transcriptomics to determine how VSG impacts different cell lineages of the small intestinal epithelium. We define cell type-specific genes and pathways that VSG rescues from high-fat diet perturbation and characterize additional rescue-independent changes brought about by VSG. We show that Paneth cells have increased expression of the gut peptide Reg3g after VSG. We also find that VSG restores pathways pertaining to mitochondrial respiration and cellular metabolism, especially within crypt-based cells. Overall, our study provides unprecedented molecular resolution of VSG's therapeutic effects on the gut epithelium.

Indexed as

GastrectomyObesityAnimalsDiet, High-FatHumansIntestinal MucosaMiceBariatric surgeryIntestineObesitySingle-cell transcriptomicsVertical sleeve gastrectomy

Identifiers

PMID38309446
PMCPMC10959023
OpenAlexW4391672875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.