Evidence map›Paper›PMID 38309427›Full record

ArticleThe American journal of pathology2024

PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome.

Emilia Anouk Margo Firat, Eva Miriam Buhl, Nassim Bouteldja, Bart Smeets, Ulf Eriksson, Peter Boor, Barbara Mara Klinkhammer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Emilia Anouk Margo FiratInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
Eva Miriam BuhlInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany.
Nassim BouteldjaInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
Bart SmeetsDepartment of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
Ulf ErikssonDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Peter BoorInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany; Department of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany. Electronic address: pboor@ukaachen.de.
Barbara Mara KlinkhammerInstitute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.
Universitätsklinikum Aachen · DEKarolinska Institutet · SERadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alport syndrome is an inherited kidney disease, which can lead to glomerulosclerosis and fibrosis, as well as end-stage kidney disease in children and adults. Platelet-derived growth factor-D (PDGF-D) mediates glomerulosclerosis and interstitial fibrosis in various models of kidney disease, prompting investigation of its role in a murine model of Alport syndrome. In vitro, PDGF-D induced proliferation and profibrotic activation of conditionally immortalized human parietal epithelial cells. In Col4a3

Indexed as

Nephritis, HereditaryAnimalsCollagen Type IVFibrosisKidneyLymphokinesMiceMice, KnockoutPlatelet-Derived Growth FactorCollagen Type IVLymphokinesPdgfd protein, mousePlatelet-Derived Growth Factor

Identifiers

PMID38309427
PMCPMC12178340
OpenAlexW4391424709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.