Evidence map›Paper›PMID 38309322›Full record

ArticleBiological psychiatry2024

Imaging the Vesicular Acetylcholine Transporter in Schizophrenia: A Positron Emission Tomography Study Using [

Jodi J Weinstein, Scott J Moeller, Greg Perlman, Roberto Gil, Jared X Van Snellenberg, Kenneth Wengler, Jiayan Meng, Mark Slifstein, Anissa Abi-Dargham

Abstract read
In one paragraph

Article in Biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Brain cholinergic terminal density utilizing [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jodi J WeinsteinDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York; Department of Psychiatry, Columbia University Vagelos School of Medicine and New York State Psychiatric Institute, New York, New York. Electronic address: jodi.weinstein@stonybrookmedicine.edu.
Scott J MoellerDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.
Greg PerlmanDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.
Roberto GilDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.
Jared X Van SnellenbergDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; Department of Psychology, Stony Brook University, Stony Brook, New York.
Kenneth WenglerDepartment of Psychiatry, Columbia University Vagelos School of Medicine and New York State Psychiatric Institute, New York, New York; Department of Radiology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.
Jiayan MengDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.
Mark SlifsteinDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.
Anissa Abi-DarghamDepartment of Psychiatry and Behavioral Health, Stony Brook University Renaissance School of Medicine, Stony Brook, New York; Department of Psychiatry, Columbia University Vagelos School of Medicine and New York State Psychiatric Institute, New York, New York.
Stony Brook School · USNew York Psychoanalytic Society and Institute · US

Funding

Towards an Integrated Understanding of Neurotransmitter Dysfunction in Schizophrenia: a Multimodal MRI StudyK23MH115291 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI WEINSTEIN, JODI JAY · 2018 to 2024
$1.2M
Functional MRI in SchizophreniaR21MH126260 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DAI, WEIYING, HE, XIANG · 2022 to 2023
$467k
NIMH NIH HHS K23 MH115291NIMH NIH HHS R21 MH126260
6 · The paper itself

Abstract

backgroundDespite longstanding interest in the central cholinergic system in schizophrenia (SCZ), cholinergic imaging studies with patients have been limited to receptors. Here, we conducted a proof-of-concept positron emission tomography study using [

methodsA total of 18 adult patients with SCZ or schizoaffective disorder (the SCZ group) and 14 healthy control participants underwent a positron emission tomography scan with [

resultsNo group differences in [

conclusionsIn this initial study, the severity of 2 important features of SCZ-psychosis and working memory deficit-was strongly associated with [

Indexed as

Positron-Emission TomographyPsychotic DisordersSchizophreniaVesicular Acetylcholine Transport ProteinsAdultBrainFemaleFluorine RadioisotopesHumansMaleMiddle AgedRadiopharmaceuticalsFluorine RadioisotopesRadiopharmaceuticalsVesicular Acetylcholine Transport Proteins[(18)F]-VAT positron emission tomography (PET)AcetylcholineCognitive impairmentNeuroimagingPsychosisVesicular acetylcholine transporter (VAChT)

Identifiers

PMID38309322
PMCPMC13366354
OpenAlexW4391467701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.