Evidence map›Paper›PMID 38309106›Full record

ReviewCurrent opinion in neurobiology2024

Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions?

Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccillo

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Dual cholinergic mechanisms for sculpting striatal dopamine in vivo.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Neuroplasticity in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Elizabeth N HollyCenter for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Ave, Newark, NJ 07102, USA. Electronic address: https://twitter.com/ENHolly.
Jamie GalanaughNeuroscience Graduate Group, Perelman School of Medicine at the University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA. Electronic address: https://twitter.com/jamie_galanaugh.
Marc V FuccilloDepartment of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA. Electronic address: fuccillo@pennmedicine.upenn.edu.
University of Pennsylvania · USRutgers, The State University of New Jersey · US

Funding

A Novel Role for Local Striatal Interneuron Regulation of Goal-Directed ActionR01MH118369 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FUCCILLO, MARC V · 2020 to 2024
$2.8M
Novel Role of a Ventral Striatal Circuit in Motor ControlR01NS117061 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI FUCCILLO, MARC V, MA, MINGHONG · 2021 to 2025
$2.4M
Effects of adolescent social isolation on adult decision making and corticostriatal circuitryK01MH127306 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI HOLLY, ELIZABETH N. · 2021 to 2024
$773k
NIMH NIH HHS K01 MH127306NIMH NIH HHS R01 MH118369NINDS NIH HHS R01 NS117061
6 · The paper itself

Abstract

Striatal dopamine governs a wide range of behavioral functions, yet local dopamine concentrations can be dissociated from somatic activity. Here, we discuss how dopamine's diverse roles in behavior may be driven by local circuit mechanisms shaping dopamine release. We first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to GABAergic and cholinergic local circuit mechanisms. Then we discuss some of the first in vivo studies of acetylcholine-dopamine interactions in striatum and broadly discuss necessary future work in understanding the roles of midbrain versus striatal dopamine regulation.

Indexed as

Corpus StriatumDopamineAcetylcholineDopaminergic NeuronsAcetylcholineDopamine

Identifiers

PMID38309106
PMCPMC11066854
OpenAlexW4391509985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.