Evidence map›Paper›PMID 38308921›Full record

ArticleThe journal of nutrition, health & aging2024

Risk of mortality in older adults with loss of appetite: An analysis of Medicare fee-for-service data.

Simon Dagenais, Sunday Clark, Roger A Fielding, Cera Cantu, Sapna Prasad, Feng Dai, John D Groarke

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Article in The journal of nutrition, health & aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Simon DagenaisPfizer, New York, NY, USA. Electronic address: simon.dagenais@pfizer.com.
Sunday ClarkPfizer, New York, NY, USA.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, MA, USA.
Cera CantuClarify Health, San Francisco, CA, USA.
Sapna PrasadClarify Health, San Francisco, CA, USA.
Feng DaiPfizer, New York, NY, USA.
John D GroarkePfizer, Cambridge, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrior research suggested that loss of appetite (LOA) among adults with Medicare fee-for-service (FFS) insurance in the United States increased the risk of mortality within 1 year; those findings were not adjusted for risk factors and confounders. The objective of this study was to compare the risk of mortality among Medicare FFS beneficiaries with LOA to a control group without LOA while controlling or adjusting for age, comorbidities, body mass index (BMI), and weight loss.

designRetrospective and observational analysis of Medicare FFS health insurance claims data from October 1, 2015 to December 31, 2021.

settingClaims from all settings (e.g., hospital inpatient/outpatient, office, assisted living facility, skilled nursing facility, hospice, rehabilitation facility, home) were included in these analyses.

participantsThe LOA group included all individuals aged 65-115 years with continuous Medicare FFS medical coverage (Parts A and/or B) for at least 12 months before a claim with ICD-10 diagnosis code "R63.0 Anorexia". The control group was drawn from individuals aged 65-115 years with continuous Medicare FFS coverage who did not have a diagnosis of R63.0. Individuals with LOA were matched 1:3 to those in the control group based on age, sex, and race/ethnicity. MEASUREMENTS: Mortality in the LOA group was compared to mortality in the control group using Kaplan-Meier and Cox regression analyses and stratified or adjusted in terms of Charlson Comorbidity Index (CCI), claims-based frailty index (CFI), BMI, and weight loss.

resultsThe study population of 1,707,031 individuals with LOA and 5,121,093 controls without LOA was 61.7% female and 82.2% White. More individuals with LOA compared with the control group had a CCI score 5+ (52.4% vs. 19.4%), CFI score 5+ (31.6% vs. 6.4%), and BMI < 20 kg/m

conclusionIndividuals with LOA had a substantially increased risk of death even after matching for age, sex, race/ethnicity, and adjusting for comorbidities. These findings highlight the burden of illness in older adults with LOA and the need for therapies.

Indexed as

AnorexiaMedicareAgedAppetiteFemaleHumansMaleRetrospective StudiesUnited StatesWeight LossAnorexia of agingClaimsLoss of appetiteMedicareOlder adults

Identifiers

PMID38308921
PMCPMC12880482

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