ArticleThe Journal of clinical endocrinology and metabolism2024
Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Meta-analysis of machine learning models for the diagnosis of central precocious puberty based on clinical, hormonal (laboratory) and imaging data.Frontiers in endocrinology · 2024Pooled it
- Idiopathic Central Precocious Puberty in Boys: Results from a National Portuguese Cohort.Hormone research in paediatrics · 2026Article
- MECP2 Rare Variants in Boys With Central Precocious Puberty.The Journal of clinical endocrinology and metabolism · 2026Article
- MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty.Frontiers in endocrinology · 2026Article
- Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.Frontiers in endocrinology · 2026Review
- Central Precocious Puberty and Hypothalamic Teratoma.JCEM case reports · 2026Article
- Unveiling the gut: microbiota and derived metabolites' role in the rising tide of precocious puberty.Frontiers in microbiology · 2026Review
- Central Precocious Puberty in Males, GnRH Analog Treated or Untreated, Did Not Impact Fertility and Health in Midadulthood.The Journal of clinical endocrinology and metabolism · 2025Article
- Central precocious puberty in boys; diagnosis, treatment and follow-up: a nation-wide study.Endocrine · 2025Article
- Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion.Endocrine connections · 2025Article
- Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study.Frontiers in endocrinology · 2025Article
- High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation.Frontiers in endocrinology · 2025Article
- Minimizing unnecessary brain magnetic resonance imaging in pediatric endocrinology: a retrospective cohort analysis.Frontiers in endocrinology · 2024Article
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Authors and funding
27 authors at 17 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThere are only a few nationwide studies on boys with central precocious puberty (CPP) and the last Italian study is a case series of 45 boys that dates back to 2000.
objectiveWe aimed to evaluate the causes of CPP in boys diagnosed during the last 2 decades in Italy and the relative frequency of forms with associated central nervous system (CNS) abnormalities on magnetic resonance imaging (MRI) compared to idiopathic ones.
methodsWe performed a national multicenter retrospective study collecting data from 193 otherwise normal healthy boys with a diagnosis of CPP. Based on MRI findings, the patients were divided into: Group 1, no CNS abnormalities; Group 2, mild abnormalities (incidental findings) unrelated to CPP; and Group 3, causal pathological CNS abnormalities.
resultsThe MRI findings show normal findings in 86%, mild abnormalities (incidental findings) in 8.3%, and causal pathological CNS abnormalities in 5.7% of the cases. In Group 3, we found a higher proportion of patients with chronological age at diagnosis < 7 years (P = .00001) and body mass index greater than +2 SDS (P < .01). Gonadotropin-releasing hormone analogue therapy was started in 183/193 subjects. The final height appeared in the range of the target height in all groups and in 9 patients in whom the therapy was not started.
conclusionIn our study on a large nationwide cohort of boys referred for precocious puberty signs, the percentage of forms associated with CNS abnormalities was one of the lowest reported in the literature.
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