Evidence map›Paper›PMID 38308730›Full record

ReviewStem cell reviews and reports2024

Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases.

Mohammad Kiarashi, Hannaneh Bayat, Seyed Abbas Shahrtash, Enas Abdalla Etajuri, Meysam Mohammadi Khah, Nadhim Allawi Al-Shaheri, Kamyar Nasiri, Mahla Esfahaniani, Saman Yasamineh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Mohammad KiarashiCollege of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran.
Hannaneh BayatTehran University of Medical Science, Tehran, Iran.
Seyed Abbas ShahrtashDepartment of Pharmaceutical Engineering, University of Tehran, Tehran, Iran.
Enas Abdalla EtajuriDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Meysam Mohammadi KhahDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nadhim Allawi Al-ShaheriDepartment of Anesthesiology, Al-Noor University College, Nineveh, Iraq.
Kamyar NasiriDepartment of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran. kamyar.nasiri.dds@gmail.com.
Mahla EsfahanianiFaculty of Dentistry, Golestan University of Medical Sciences, Gorgan, Iran. Mahlaesfahaniani@gmail.com.
Saman YasaminehYoung Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Yassaman124@gmail.com.ORCID 0009-0004-9016-6975
University of Tehran · IRAl-Nisour University College · IQGolestan University · IRIslamic Azad University Medical Branch of Tehran · IRIslamic Azad University of Tabriz · IRLorestan University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomedical engineering breakthroughs and increased patient expectations and requests for more comprehensive care are propelling the field of regenerative dentistry forward at a fast pace. Stem cells (SCs), bioactive compounds, and scaffolds are the mainstays of tissue engineering, the backbone of regenerative dentistry. Repairing damaged teeth and gums is a significant scientific problem at present. Novel therapeutic approaches for tooth and periodontal healing have been inspired by tissue engineering based on mesenchymal stem cells (MSCs). Furthermore, as a component of the MSC secretome, extracellular vesicles (EVs) have been shown to contribute to periodontal tissue repair and regeneration. The scaffold, made of an artificial extracellular matrix (ECM), acts as a supporting structure for new cell development and tissue formation. To effectively promote cell development, a scaffold must be non-toxic, biodegradable, biologically compatible, low in immunogenicity, and safe. Due to its promising biological characteristics for cell regeneration, dental tissue engineering has recently received much attention for its use of natural or synthetic polymer scaffolds with excellent mechanical properties, such as small pore size and a high surface-to-volume ratio, as a matrix. Moreover, as a bioactive material for carrying MSC-EVs, the combined application of scaffolds and MSC-EVs has a better regenerative effect on dental diseases. In this paper, we discuss how MSCs and MSC-derived EV treatment may be used to regenerate damaged teeth, and we highlight the role of various scaffolds in this process.

Indexed as

Mesenchymal Stem CellsStomatognathic DiseasesHumansRegenerative MedicineStem CellsTissue EngineeringDental diseasesMesenchymal stem cellRegenerative medicineScaffoldsTreatment

Identifiers

PMID38308730
OpenAlexW4391509711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.