Evidence map›Paper›PMID 38308696›Full record

ArticleCellular and molecular life sciences : CMLS2024

Intervertebral disc-intrinsic Hedgehog signaling maintains disc cell phenotypes and prevents disc degeneration through both cell autonomous and non-autonomous mechanisms.

Lei Zhang, Siyuan Hu, Chunmei Xiu, Meng Li, Yixin Zheng, Rui Zhang, Bin Li, Jianquan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lei Zhang *Department of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China.
Siyuan Hu *Orthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Chunmei Xiu *Department of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China.
Meng Li *Orthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Yixin ZhengOrthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Rui ZhangOrthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, 215006, Jiangsu, China.
Bin LiDepartment of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China. binli@suda.edu.cn.
Jianquan ChenDepartment of Clinical Medicine, Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, 310015, Zhejiang, China. chenjq@hzcu.edu.cn.ORCID http://orcid.org/0000-0002-0468-6287
Soochow University · CNHangzhou City University

Funding

National Natural Science Foundation of China 82272543, 81772294, 81974344
6 · The paper itself

Abstract

Intervertebral disc degeneration is closely related to abnormal phenotypic changes in disc cells. However, the mechanism by which disc cell phenotypes are maintained remains poorly understood. Here, Hedgehog-responsive cells were found to be specifically localized in the inner annulus fibrosus and cartilaginous endplate of postnatal discs, likely activated by Indian Hedgehog. Global inhibition of Hedgehog signaling using a pharmacological inhibitor or Agc1-CreER

Indexed as

Annulus FibrosusIntervertebral DiscIntervertebral Disc DegenerationAnimalsHedgehog ProteinsMicePhenotypeHedgehog ProteinsChondrocyte-like cellsDis cell differentiationGli3 repressorIntervertebral disc homeostasisLow back painShh signaling

Identifiers

PMID38308696
PMCPMC10838248
OpenAlexW4391512852

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.