Evidence map›Paper›PMID 38308490›Full record

ReviewAllergy2024

The skin microbiome in pediatric atopic dermatitis and food allergy.

Elizabeth Huiwen Tham, Minghao Chia, Carmen Riggioni, Niranjan Nagarajan, John E A Common, Heidi H Kong

Open access · hybridAbstract readReview
In one paragraph

Review in Allergy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
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  9. Review
  10. Article
  11. Skin and gut microbiome in atopic dermatitis: Mechanisms and therapeutic opportunities.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Skin microbiota: pathogenic roles and implications in atopic dermatitis.Frontiers in cellular and infection microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elizabeth Huiwen ThamKhoo Teck Puat-National University Children's Medical Institute, National University Health System (NUHS), Singapore City, Singapore.
Minghao ChiaGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore.
Carmen RiggioniDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore City, Singapore.
Niranjan NagarajanGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore.
John E A CommonA*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore.ORCID 0000-0002-3280-7365
Heidi H KongNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Agency for Science, Technology and Research · SGNational University of Singapore · SGNational Institutes of Health · US

Funding

Studies of human microbes and potential perturbationsZIAAR041219 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$4.3M
Investigation of the natural history and pathogenesis of skin diseasesZIAAR041218 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$745k
Agency for Science, Technology and ResearchIntramural NIH HHS Z99 AR999999National Medical Research CouncilNIH HHS
6 · The paper itself

Abstract

The skin microbiome is an extensive community of bacteria, fungi, mites, viruses and archaea colonizing the skin. Fluctuations in the composition of the skin microbiome have been observed in atopic dermatitis (AD) and food allergy (FA), particularly in early life, established disease, and associated with therapeutics. However, AD is a multifactorial disease characterized by skin barrier aberrations modulated by genetics, immunology, and environmental influences, thus the skin microbiome is not the sole feature of this disease. Future research should focus on mechanistic understanding of how early-life skin microbial shifts may influence AD and FA onset, to guide potential early intervention strategies or as microbial biomarkers to identify high-risk infants who may benefit from possible microbiome-based biotherapeutic strategies. Harnessing skin microbes as AD biotherapeutics is an emerging field, but more work is needed to investigate whether this approach can lead to sustained clinical responses.

Indexed as

Dermatitis, AtopicFood HypersensitivityMicrobiotaSkinChildHumansatopic dermatitisfood allergymicrobiotaskin microbiomeStaphylococcus aureus

Identifiers

PMID38308490
PMCPMC11142881
OpenAlexW4391514378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.