Evidence map›Paper›PMID 38308340›Full record

ArticleJournal of cardiothoracic surgery2024

Histopathology reveals concealed aortic valve inflammation.

Mona Laaksonen, Ivana Kholova, Timo Paavonen, Ari Mennander

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mona LaaksonenFaculty of Medicine and Health Technology, Tampere University Heart Hospital and Tampere University, SDSKIR, Elämänaukio 1, P.O. Box 2000, 33521, Tampere, Finland.
Ivana KholovaFimlab Laboratories, Department of Pathology, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland.
Timo PaavonenFimlab Laboratories, Department of Pathology, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland.
Ari MennanderFaculty of Medicine and Health Technology, Tampere University Heart Hospital and Tampere University, SDSKIR, Elämänaukio 1, P.O. Box 2000, 33521, Tampere, Finland. ari.mennander@sydansairaala.fi.
Tampere University · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe extent of aortic valve inflammation in patients undergoing aortic valve replacement (AVR) is unsettled. The significance of aortic valve histopathology in patients undergoing AVR is undetermined.

methodsA total of 145 resected aortic valves of consecutive patients undergoing surgery for a local aortic valve disease with or without ascending aorta were investigated for histopathology. The extent of inflammation and degeneration were investigated. Unadjusted survival was evaluated by Kaplan-Meier analysis. Median follow-up was 2.7 years (interquartile range 1.5-3.9).

resultsMean patient age was 69 (SD 11) years. Though endocarditis was apparent in only six patients preoperatively, severe aortic valve inflammation was diagnosed histologically in 32 patients of whom 12 patients had acute, subacute or chronic endocarditis. Despite complete aortic valve resection, survival was decreased in patients with severe aortic valve inflammation as opposed to those without (log rank, P = 0.044), even after exclusion of patients with endocarditis, emergency and aortic surgery.

conclusionsAortic valve tissue analysis reveals severe inflammation that may require postoperative treatment. The association of severe but local aortic valve inflammation with patient outcome after aortic valve surgery merits further investigation.

Indexed as

EndocarditisHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationAgedAortic ValveHumansInflammationRetrospective StudiesTreatment OutcomeAortic valve inflammationAortic valve surgeryEndocarditis

Identifiers

PMID38308340
PMCPMC10837945
OpenAlexW4391469795

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.