Trial reportBMC oral health2024
The effectiveness of low-level laser therapy and low-intensity pulsed ultrasound in reducing pain induced by orthodontic separation: a randomized controlled trial.
Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and pain perception in human studies: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- The effect of pharmacological and non-pharmacological interventions on pain control after orthodontic treatment: a systematic review and network meta-analysis.BMC oral health · 2026Pooled it
- Research Hotspots and Emerging Trends of Orthodontic-Related Discomfort and Pain: A Bibliometric Review.Pain research & management · 2025Pooled it
- Efficacy of a simplified photobiomodulation protocol in orthodontic patients: a randomized crossover clinical trial.Dental press journal of orthodontics · 2026Trial
- Efficacy of focused low intensity pulsed ultrasound in reducing lower-extremity swelling and pain after total knee arthroplasty: a randomized study.International orthopaedics · 2025Trial
- Effect of low-intensity pulsed ultrasound on the duration of mandibular anterior crowding correction and pain perception in adults undergoing orthodontic treatment: a single-blinded randomized control trial.Dental press journal of orthodontics · 2025Trial
- Review
- Early Physiotherapy of Post-Surgical Scars Using a Topical Cannabidiol (VeroDol CBD) Cream Gel: Three Case Reports.Journal of cosmetic dermatology · 2026Article
- Acupressure versus paracetamol for short-term orthodontic pain: A randomized clinical trial.Journal of Taibah University Medical Sciences · 2026Article
- Effect of ultrasound therapy for orthodontic pain control: A pilot randomized clinical trial.Bioinformation · 2026Article
- Optimizing orthodontic results with low-intensity pulsed ultrasound: A literature review.Dental research journal · 2026Review
- Efficacy of low-level laser therapy in pain relief during orthodontic treatment: Protocol for a systematic review and meta-analysis.PloS one · 2026Article
- A scientometric study on research trends and characteristics of randomized controlled trials in orthodontics.Journal of dental sciences · 2026Article
- LIPUS as a potential strategy for anti-inflammation and repair: A review of the mechanisms.International journal of medical sciences · 2026Review
- Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound.Smart medicine · 2025Review
- Article
- Comparative assessment between chewing gum, bite wafers, and ibuprofen in pain control following separators placement among orthodontic patients.The Saudi dental journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS) have been recently applied to control pain during orthodontic treatment.
objectiveTo evaluate and compare the effectiveness of LLLT and LIPUS in reducing pain induced by orthodontic separation. STUDY
designA single-blinded randomized controlled trial.
methodsOne hundred and fifty patients were randomly assigned into three groups; LLLT group, LIPUS group, and control group. After 5 min from the separators' placement, the first dose of the laser or the ultrasound was applied, the second dose was applied after 24 h, and the third dose was applied after 48 h on both maxillary and mandibular first molars. The exposure of laser was for 20 s at each point (maxillary and mandibular first molars), with an 810-nm aluminum-gallium-arsenide (AlGaAs) diode laser on continuous mode. The output power set at 150 mW, the energy density of 4 J/cm
resultsA total of 145 patients were assessed. There was a significant difference in pain perception among the three groups after 5 min (P = .002). The maximum pain level was reached after 24 h. However, the laser group and the ultrasound group showed a statistically significant decrease in pain scores compared to the control group at all the assessment time points (P < .001). Whereas there was no difference between the laser group and the ultrasound group in reducing the pain scores (P > .05).
conclusionsThe LLLT and the LIPUS effectively reduce the separation pain when applied in multiple doses without differences between them.
trial registrationThis trial was registered with the German Clinical Trials Register (DRKS). ( https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID= DRKS00029991). Date of registration: 26/08/2022.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.