Evidence map›Paper›PMID 38308160›Full record

ArticleAnnals of surgical oncology2024

The Efficacy and Safety of an Indocyanine Green-Macroaggregated Albumin-Hyaluronic Acid Mixture (LuminoMark™) for Surgical Localization of Recurrent Thyroid Cancer.

Seok-Ki Kim, Jungirl Seok, Chang Yoon Lee, Chang Hwan Ryu, Sung Yong Choi, Seog Yun Park, Young Ki Lee, Yul Hwangbo, Eun Kyung Lee, You Jin Lee and 5 more

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Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Seok-Ki Kim *Department of Nuclear Medicine, National Cancer Center, Goyang, Republic of Korea.
Jungirl Seok *Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Chang Yoon LeeDepartment of Radiology, National Cancer Center, Goyang, Republic of Korea.
Chang Hwan RyuDepartment of Otorhinolaryngology-Head and Neck Surgery, National Cancer Center, Goyang, Republic of Korea.
Sung Yong ChoiDepartment of Otorhinolaryngology-Head and Neck Surgery, National Cancer Center, Goyang, Republic of Korea.
Seog Yun ParkDepartment of Pathology, National Cancer Center, Goyang, Republic of Korea.
Young Ki LeeDepartment of Internal Medicine, National Cancer Center, Goyang, Republic of Korea.
Yul HwangboDepartment of Internal Medicine, National Cancer Center, Goyang, Republic of Korea.
Eun Kyung LeeDepartment of Internal Medicine, National Cancer Center, Goyang, Republic of Korea.
You Jin LeeDepartment of Internal Medicine, National Cancer Center, Goyang, Republic of Korea.
Sohyun ParkDepartment of Nuclear Medicine, National Cancer Center, Goyang, Republic of Korea.
Tae Sung KimDepartment of Nuclear Medicine, National Cancer Center, Goyang, Republic of Korea.
Tae Hyun KimDepartment of Radiation Oncology, National Cancer Center, Goyang, Republic of Korea.
Junsun RyuDepartment of Otorhinolaryngology-Head and Neck Surgery, National Cancer Center, Goyang, Republic of Korea.
Yuh-Seog JungDepartment of Otorhinolaryngology-Head and Neck Surgery, National Cancer Center, Goyang, Republic of Korea. jysorl@ncc.re.kr.

Funding

National Cancer Center, Republic of Korea NCC2212460-2National Cancer Center, Republic of Korea NCC2310622
6 · The paper itself

Abstract

backgroundThe recurrence of thyroid cancer poses challenges compounded by postoperative fibrosis and anatomic changes. By overcoming the limitations of current localizing dye techniques, indocyanine green-macroaggregated albumin-hyaluronic acid (ICG-MAA-HA) mixture dye promises improved localization. This study aimed to evaluate the efficacy and safety of the dye for recurrent thyroid cancer.

methodsThe nine patients in this study underwent surgery and postoperative ultrasonography. The dye was injected into recurrent lesions in all the patients preoperatively. During surgery, the lesions were confirmed with an imaging system before and after excision. If the lesion was unidentifiable with the naked eye, surgical excision was performed under the corresponding fluorescent guide. Side effects related to the dye injection and completeness of the surgery were evaluated.

resultsNo side effects such as bleeding, skin tattooing, or pain during or after the dye injection were reported, and no discoloration occurred that interfered with the surgical field of view during surgery. In three cases (33.3 %), because it was difficult to localize metastatic lesions with the naked eye, the operation was successfully completed using an imaging system. The completeness of the surgical resection was confirmed by ultrasonography after an average of 5 months postoperatively.

conclusionThe study found that ICG-MAA-HA dye effectively located metastatic and recurrent thyroid cancer and had favorable results in terms of minimal procedural side effects and potential for assisting the surgeon. A large-scale multi-institutional study is necessary to prove the clinical significance regarding patient survival and disease control.

Indexed as

Indocyanine GreenThyroid NeoplasmsAlbuminsColoring AgentsHumansHyaluronic AcidSentinel Lymph Node BiopsyAlbuminsColoring AgentsHyaluronic AcidIndocyanine GreenFluorescenceIndocyanine greenLocalizationMetastatic lymph nodeThyroid cancer

Identifiers

PMID38308160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.