Nucleated Red Blood Cell Counts Differentiate Cardiac from Respiratory Causes of Cyanosis at Birth.

Deepank Sahni, Yamuna Sanil, Ronald Thomas, Robert D Ross

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Article in Pediatric cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Deepank SahniDivision of Cardiology, Central Michigan University College of Medicine, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.

Yamuna SanilDivision of Cardiology, Central Michigan University College of Medicine, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA. ysanil@dmc.org.

Ronald ThomasCarman and Ann Adams Department of Pediatrics, Central Michigan University College of Medicine, Children's Hospital of Michigan, Detroit, USA.

Robert D RossDivision of Cardiology, Central Michigan University College of Medicine, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue hypoxia increases erythropoietin production and release of immature erythrocytes that can be measured using nucleated red blood cell counts (nRBC). We hypothesized that hypoxia due to congenital heart disease (CHD) is chronic and is better tolerated than hypoxia due to respiratory disease (RD), which is an acute stress in newborns leading to higher nRBC. This study assesses the utility of nRBC as a marker to differentiate hypoxia due to CHD vs RD in term neonates. This was a single-center, retrospective study of term neonates with cyanosis from 2015 to 2022. Neonates < 37 weeks of gestation, with hypoxic-ischemic encephalopathy, and those with other causes of cyanosis were excluded. The patients were divided into 2 groups: cyanotic CHD and cyanotic RD. Clinical and laboratory data done within 12 h and 24-36 h after birth were collected. Data are represented as median and Interquartile range. Of 189 patients with cyanosis, 80 had CHD and 109 had RD. The absolute nRBC count at ≤ 12 h of age was lower in the CHD (360 cells/mm

Indexed as

ErythroblastsHeart Defects, CongenitalCyanosisErythrocyte CountHumansHypoxiaInfant, NewbornRetrospective StudiesCyanosis in newbornCyanotic congenital heart diseaseCyanotic respiratory diseaseNucleated red blood cells

Identifiers

PMID38308060

DOI10.1007/s00246-024-03409-9

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.