Observational studyJournal of perinatology : official journal of the California Perinatal Association2024
A new algorithm DEtectS critical Congenital Heart Disease at different altitudes: ANDES-CHD study.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Congenital heart disease-related mortality during the first year of life: The peruvian experience.International journal of cardiology. Congenital heart disease · 2025Article
- Protocol for a prospective cohort study on congenital heart disease in neonates across varied altitudes in Sichuan province, China.PloS one · 2025Article
- [Neonatal screening for critical congenital heart diseases in Peru: an urgent call].Archivos peruanos de cardiologia y cirugia cardiovascularReview
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Authors and funding
22 authors at 14 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal pulse oximetry screening (POS) algorithms for critical congenital heart disease (CCHD) have contributed towards decreasing neonatal mortality but cannot be applied at high altitudes. New POS algorithms at high altitudes are needed.
methodsThis observational, prospective study included newborns born at different altitudes from 0 to 4380 meters above the sea level in Peru. Healthy newborns underwent neonatal preductal and postductal oximetry, echocardiography and telephonic follow-up up to 12 months of age. Newborns with CCHD underwent preductal and postductal oximetry at the time of telemedicine evaluation while located at the high-altitude hospital where they were born, and their diagnoses were confirmed with echocardiography locally or after arriving to the referral center. Two new algorithms were designed using clinically accepted neonatal oximetry cutoffs or the 5th and 10th percentiles for preductal and postductal oximetry values.
resultsA total of 502 healthy newborns and 15 newborns with CCHD were enrolled. Echocardiography and telephonic follow-up were completed in 227 (45%) and 330 healthy newborns (65%), respectively. The algorithm based on clinically accepted cutoffs had a sensitivity of 92%, specificity of 73% and false positive rate of 27% The algorithm based on the 5th and 10th percentiles had a sensitivity of 80%, specificity of 88% and false positive rate of 12%.
conclusionsTwo algorithms that detect CCHD at different altitudes had adequate performance but high false positive rates.
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