Observational studyScientific reports2024
Demographic and clinical characteristics of patients with zinc deficiency: analysis of a nationwide Japanese medical claims database.
Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.Nutrients · 2025Pooled it
- Comparative Analysis of Selected Biochemical Markers Involved in Antioxidative, Immune Responses, and Thyroid Function in Wistar Rats Fed Diets Containing Baked Sprats.Molecules (Basel, Switzerland) · 2026Article
- Metabolic and cardiovascular profiles in diabetes type 2: a comparative analysis of zinc homeostasis and blood pressure-a single center case-control study.Scientific reports · 2026Article
- Polyphenols Suppress Intracellular Zinc Deficiency-Induced ROS Production and NLRP3 Inflammasome Activation in Microglial and Neuronal Cells.Biomolecules · 2026Article
- Drinking Water Disinfection Using Nutritional Level Zinc Assisted with Electric Field Treatment.Environmental science & technology · 2026Article
- Association of Serum Zinc Status with 5-Year Clinical Outcomes in Women with Breast Cancer and Type 2 Diabetes: A Retrospective Cohort Study Using TriNetX.Healthcare (Basel, Switzerland) · 2026Article
- Valorization of Fruit and Vegetable Pomace: Development of Zinc-Enriched Nutraceutical.Foods (Basel, Switzerland) · 2026Article
- Article
- Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition.Frontiers in nutrition · 2026Review
- Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study.Frontiers in nutrition · 2026Article
- Negative impact of reduced exocrine pancreatic function on sarcopenia risk in the asymptomatic general population.Frontiers in nutrition · 2026Article
- Magnesium and Zinc Are Associated with Sleep Quality in Saudi Adults: Evidence from a Cross-Sectional Study.Nutrients · 2025Article
- Optimizing Agronomic Zinc Biofortification in Carrots.Plant-environment interactions (Hoboken, N.J.) · 2025Article
- Association of micronutrient status with thyroid function in adolescent Afghan refugees; a cross-sectional study.Thyroid research · 2025Article
- Association Between Zinc Levels and the Impact of Its Deficiency on Idiopathic Male Infertility: An Up-to-Date Review.Antioxidants (Basel, Switzerland) · 2025Review
- Dietary Micronutrient Intake and the Prevalence of Metabolic Conditions among Children from the United States-Affiliated Pacific Region in the Children's Healthy Living Program.Current developments in nutrition · 2025Article
- Zinc and Ferritin Levels and Their Associations with Functional Disorders and/or Thyroid Autoimmunity: A Population-Based Case-Control Study.International journal of molecular sciences · 2024Article
- The Impact of the Mediterranean Diet on Telomere Biology: Implications for Disease Management-A Narrative Review.Nutrients · 2024Review
- Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- The role of zinc in the premature brain: functions, outcomes and future research perspectives.Frontiers in pediatrics · 2024Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc deficiency, affecting more than 2 billion people globally, poses a significant public health burden due to its numerous unfavorable effects, such as impaired immune function, taste and smell disorders, pneumonia, growth retardation, visual impairment, and skin disorders. Despite its critical role, extensive large-scale studies investigating the correlation between patient characteristics and zinc deficiency still need to be completed. We conducted a retrospective, cross-sectional observational study using a nationwide Japanese claims database from January 2019 to December 2021. The study population included 13,100 patients with available serum zinc concentration data, excluding individuals under 20 and those assessed for zinc concentrations after being prescribed zinc-containing medication. Significant associations with zinc deficiency were noted among older adults, males, and inpatients. Multivariate analysis, adjusting for age and sex, indicated significant associations with comorbidities, including pneumonitis due to solids and liquids with an adjusted Odds Ratio (aOR) of 2.959; decubitus ulcer and pressure area (aOR 2.403), sarcopenia (aOR 2.217), COVID-19 (aOR 1.889), and chronic kidney disease (aOR 1.835). Significant association with medications, including spironolactone (aOR 2.523), systemic antibacterials (aOR 2.419), furosemide (aOR 2.138), antianemic preparations (aOR 2.027), and thyroid hormones (aOR 1.864) were also found. These results may aid clinicians in identifying patients at risk of zinc deficiency, potentially improving care outcomes.
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