Evidence map›Paper›PMID 38307823›Full record

ArticleHematology, transfusion and cell therapy2024

Functional characterization of compound heterozygosity Hb S/Hb Deer Lodge in Brazil.

Marcondes J Sobreira, Thais H Batista, Rodrigo M Santana, Gabriela S Arcanjo, Susan E Jorge, Magnun N Santos, Dulcinéia M Albuquerque, Betânia L Hatzlhofer, Ana C Dos Anjos, Fernando F Costa and 4 more

Open access · diamondAbstract read
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In one paragraph

Article in Hematology, transfusion and cell therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Marcondes J SobreiraUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil.
Thais H BatistaUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil.
Rodrigo M SantanaUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil.
Gabriela S ArcanjoUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil.
Susan E JorgeUniversidade de Campinas, Faculdade de Ciências Médicas, Departamento de Patologia Clínica, Campinas, SP, Brasil.
Magnun N SantosUniversidade de Campinas, Faculdade de Ciências Médicas, Departamento de Patologia Clínica, Campinas, SP, Brasil.
Dulcinéia M AlbuquerqueUniversidade de Campinas, Centro de Hematologia e Hemoterapia, Campinas, SP, Brasil.
Betânia L HatzlhoferUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil; Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento de Ciências Farmacêuticas, Recife, PE, Brasil.
Ana C Dos AnjosFundação de Hematologia e Hemoterapia de Pernambuco, Departamento de Medicina Interna, Recife, PE, Brasil.
Fernando F CostaUniversidade de Campinas, Centro de Hematologia e Hemoterapia, Campinas, SP, Brasil.
Aderson S AraujoFundação de Hematologia e Hemoterapia de Pernambuco, Departamento de Medicina Interna, Recife, PE, Brasil.
Maria F SonatiUniversidade de Campinas, Faculdade de Ciências Médicas, Departamento de Patologia Clínica, Campinas, SP, Brasil.
Antonio R Lucena-AraujoUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil.
Marcos A BezerraUniversidade Federal de Pernambuco, Programa de Pós-Graduação em Genética, Recife, PE, Brasil. Electronic address: macbezerra.ufpe@gmail.com.
Universidade Federal de Pernambuco · BRUniversidade Estadual de Campinas (UNICAMP) · BRFundação Hemopa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Hb Deer Lodge (β2 His>Arg; HBB:c.8A>G) is a structural hemoglobin variant described in some populations around the world, characterized by increased oxygen affinity, but does not confer clinical symptoms to its carriers. The coinheritance of the Hb Deer Lodge with the most common hemoglobin variant, Hb S, has been reported only once; however, functional data were not described. Here we show a case of the Hb S and Hb Deer Lodge carrier in heterozygosity.

methodsThe Hb S and Hb Deer Lodge association was identified by High-Performance Liquid Chromatography (HPLC), reverse phase HPLC and the β globin gene sequencing. The functional characterization of this interaction was obtained using the O

resultsWhen the Hb S and Hb Deer Lodge were associated, there was a decrease in cooperativity, no significant changes in oxygen affinity and no significant Bohr effect changes.

conclusionDespite these genetic variations, the carrier showed no hematological alterations and no clinical symptoms, possibly due to the high oxygen affinity of the Hb Deer Lodge, which interferes with the Hb S polymerization.

Indexed as

Hemoglobin Deer LodgeHemoglobin variantSickle cell disease

Identifiers

PMID38307823
PMCPMC11670527
OpenAlexW4389448453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.