Evidence map›Paper›PMID 38307536›Full record

ArticleBMJ open2024

Clinical and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) for people living with dementia and their carers: a study protocol for a parallel multicentre randomised controlled trial.

Penny Rapaport, Sarah Amador, Mariam Adeleke, Sube Banerjee, Julie Barber, Georgina Charlesworth, Christopher Clarke, Caroline Connell, Colin Espie, Lina Gonzalez and 11 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The DREAMS START intervention for sleep in dementia: Long-term follow-up of a randomized controlled trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  2. Trial
  3. Trial
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Penny RapaportDivision of Psychiatry, University College London, London, UK p.rapaport@ucl.ac.uk.
Sarah AmadorDivision of Psychiatry, University College London, London, UK.ORCID 0000-0003-4196-6410
Mariam AdelekeDepartment of Statistical Science, University College London, London, UK.
Sube BanerjeeFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.
Julie BarberDepartment of Statistical Science, University College London, London, UK.
Georgina CharlesworthDivision of Psychology and Language Sciences, University College London, London, UK.
Christopher ClarkeTees Esk and Wear Valleys NHS Foundation Trust, Darlington, UK.
Caroline ConnellTees Esk and Wear Valleys NHS Foundation Trust, Darlington, UK.
Colin EspieSleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
Lina GonzalezResearch Department of Primary Care and Population Health, University College London, London, UK.
Rossana HorsleyAlzheimer's Society, London, UK.
Rachael HunterResearch Department of Primary Care and Population Health, University College London, London, UK.ORCID 0000-0002-7447-8934
Simon D KyleSleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.ORCID 0000-0002-9581-5311
Monica ManelaDivision of Psychiatry, University College London, London, UK.
Sarah MorrisTees Esk and Wear Valleys NHS Foundation Trust, Darlington, UK.
Liam PikettDivision of Psychiatry, University College London, London, UK.
Malgorzata RaczekCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, UK.
Emma ThorntonTees Esk and Wear Valleys NHS Foundation Trust, Darlington, UK.
Zuzana WalkerDivision of Psychiatry, University College London, London, UK.
Lucy WebsterDivision of Psychiatry, University College London, London, UK.
Gill LivingstonDivision of Psychiatry, University College London, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionMany people living with dementia experience sleep disturbance and there are no known effective treatments. Non-pharmacological treatment options should be the first-line sleep management. For family carers, relatives' sleep disturbance leads to interruption of their sleep, low mood and breakdown of care. Our team developed and delivered DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives), a multimodal non-pharmacological intervention, showing it to be feasible and acceptable. The aim of this randomised controlled trial is to establish whether DREAMS START is clinically cost-effective in reducing sleep disturbances in people living with dementia living at home compared with usual care. METHODS AND ANALYSIS: We will recruit 370 participant dyads (people living with dementia and family carers) from memory services, community mental health teams and the Join Dementia Research Website in England. Those meeting inclusion criteria will be randomised (1:1) either to DREAMS START or to usual treatment. DREAMS START is a six-session (1 hour/session), manualised intervention delivered every 1-2 weeks by supervised, non-clinically trained graduates. Outcomes will be collected at baseline, 4 months and 8 months with the primary outcome being the Sleep Disorders Inventory score at 8 months. Secondary outcomes for the person with dementia (all proxy) include quality of life, daytime sleepiness, neuropsychiatric symptoms and cost-effectiveness. Secondary outcomes for the family carer include quality of life, sleep disturbance, mood, burden and service use and caring/work activity. Analyses will be intention-to-treat and we will conduct a process evaluation. ETHICS AND DISSEMINATION: London-Camden & Kings Cross Ethics Committee (20/LO/0894) approved the study. We will disseminate our findings in high-impact peer-reviewed journals and at national and international conferences. This research has the potential to improve sleep and quality of life for people living with dementia and their carers, in a feasible and scalable intervention. TRIAL REGISTRATION NUMBER: ISRCTN13072268.

Indexed as

CaregiversDementiaCost-Benefit AnalysisHumansMulticenter Studies as TopicQuality of LifeRandomized Controlled Trials as TopicSleepClinical TrialDementiaHealth Services for the Aged

Identifiers

PMID38307536
PMCPMC10836385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.