Evidence map›Paper›PMID 38307224›Full record

ArticleContemporary clinical trials2024

Optimizing an adaptive digital oral health intervention for promoting oral self-care behaviors: Micro-randomized trial protocol.

Inbal Nahum-Shani, Zara M Greer, Anna L Trella, Kelly W Zhang, Stephanie M Carpenter, Dennis Rünger, David Elashoff, Susan A Murphy, Vivek Shetty

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05624489 (Personalized Digital Behavior Change Interventions to Promote Oral Health), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05624489 nacompletednot on this map

Personalized Digital Behavior Change Interventions to Promote Oral Health

TypeinterventionalSponsorUniversity of California, Los AngelesRan2023 to 2025Enrolled98ConditionsDental DiseasesArmsEngagement Strategies
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Replicable Bandits for Digital Health Interventions.Statistical science : a review journal of the Institute of Mathematical Statistics · 2025
    Article
  6. SigmaScheduling: Uncertainty-Informed Scheduling of Decision Points for Intelligent Mobile Health Interventions.... International Conference on Wearable and Implantable Body Sensor Networks. International Conference on Wearable and Implantable Body Sensor Networks · 2025
    Article
  7. Momentary mindfulness versus distraction coping messages to reduce cannabis craving among young adults: A microrandomized trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Article
  8. Article
  9. A Deployed Online Reinforcement Learning Algorithm In An Oral Health Clinical Trial.Proceedings of the ... AAAI Conference on Artificial Intelligence. AAAI Conference on Artificial Intelligence · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Inbal Nahum-ShaniInstitute for Social Research, University of Michigan, United States of America. Electronic address: inbal@umich.edu.
Zara M GreerSchool of Dentistry, University of California, Los Angeles, United States of America.
Anna L TrellaSchool of Engineering and Applied Sciences, Harvard University, United States of America.
Kelly W ZhangSchool of Engineering and Applied Sciences, Harvard University, United States of America.
Stephanie M CarpenterCollege of Health Solutions, Arizona State University, United States of America.
Dennis RüngerDivision of General Internal Medicine and Health Services Research, University of California, Los Angeles, United States of America.
David ElashoffDivision of General Internal Medicine and Health Services Research, Department of Biostatistics, and Department of Computational Medicine, University of California, Los Angeles, United States of America.
Susan A MurphySchool of Engineering and Applied Sciences, Harvard University, United States of America.
Vivek ShettySchool of Dentistry, University of California, Los Angeles, United States of America.
University of California, Los Angeles · USHarvard University · USArizona State University · USInslaw (United States) · US

Funding

Pilot and Mentoring CoreP50DA054039 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LINDA M COLLINS, SUSAN A MURPHY · 2021 to 2026
$18.2M
TR&D3 - Rapid Translation of AI-powered Temporally Precise mHealth Interventions via Efficient and Embeddable Trustworthy Biomarker ImplementationsP41EB028242 · NIBIB · UNIVERSITY OF MEMPHIS · PI Santosh Kumar · 2020 to 2026
$9.5M
Novel Methods for Intensive Longitudinal Data in SMART Studies of Drug Abuse and HIVR01DA039901 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL, NAHUM-SHANI, INBAL BILLIE · 2015 to 2024
$5.4M
Personalized Digital Behavior Change Interventions to Promote Oral HealthUH3DE028723 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VIVEK SHETTY · 2022 to 2026
$3.8M
ROBAS: A Multimodal Sensor System for Remote Assessment of Oral Health BehaviorsR01DE025244 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHETTY, VIVEK · 2015 to 2019
$3.1M
Novel use of mHealth data to identify states of vulnerability and receptivity to JITAIs SupplementU01CA229437 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAHUM-SHANI, INBAL BILLIE, WETTER, DAVID W · 2018 to 2022
$2.8M
Personalized Digital Behavior Change Interventions to Promote Oral HealthUG3DE028723 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHETTY, VIVEK · 2019 to 2019
$460k
NCI NIH HHS U01 CA229437NIBIB NIH HHS P41 EB028242NIDA NIH HHS P50 DA054039NIDA NIH HHS R01 DA039901NIDCR NIH HHS R01 DE025244NIDCR NIH HHS UG3 DE028723NIDCR NIH HHS UH3 DE028723
6 · The paper itself

Abstract

Dental disease continues to be one of the most prevalent chronic diseases in the United States. Although oral self-care behaviors (OSCB), involving systematic twice-a-day tooth brushing, can prevent dental disease, this basic behavior is not sufficiently practiced. Recent advances in digital technology offer tremendous potential for promoting OSCB by delivering Just-In-Time Adaptive Interventions (JITAIs)- interventions that leverage dynamic information about the person's state and context to effectively prompt them to engage in a desired behavior in real-time, real-world settings. However, limited research attention has been given to systematically investigating how to best prompt individuals to engage in OSCB in daily life, and under what conditions prompting would be most beneficial. This paper describes the protocol for a Micro-Randomized Trial (MRT) to inform the development of a JITAI for promoting ideal OSCB, namely, brushing twice daily, for two minutes each time, in all four dental quadrants (i.e., 2x2x4). Sensors within an electric toothbrush (eBrush) will be used to track OSCB and a matching mobile app (Oralytics) will deliver on-demand feedback and educational information. The MRT will micro-randomize participants twice daily (morning and evening) to either (a) a prompt (push notification) containing one of several theoretically grounded engagement strategies or (b) no prompt. The goal is to investigate whether, what type of, and under what conditions prompting increases engagement in ideal OSCB. The results will build the empirical foundation necessary to develop an optimized JITAI that will be evaluated relative to a suitable control in a future randomized controlled trial.

Indexed as

Mobile ApplicationsStomatognathic DiseasesHumansOral HealthRandomized Controlled Trials as TopicSelf CareDental diseaseDigital technologyJust-in-time adaptive interventionMicro-randomized trialOral self-care behaviors

Identifiers

PMID38307224
PMCPMC11007589
OpenAlexW4391431672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.