Evidence map›Paper›PMID 38306983›Full record

ArticleCell2024

Brain-wide neural activity underlying memory-guided movement.

Susu Chen, Yi Liu, Ziyue Aiden Wang, Jennifer Colonell, Liu D Liu, Han Hou, Nai-Wen Tien, Tim Wang, Timothy Harris, Shaul Druckmann and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
26.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 86 citations in OpenAlex.

  1. Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  11. Addressing degeneracy in rodent studies of cognition.Current opinion in neurobiology · 2026
    Review
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  13. Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
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  17. Live Spike Sorting of Large-scale Neural Recordings.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Susu ChenJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Yi LiuStanford University, Palo Alto, CA, USA.
Ziyue Aiden WangStanford University, Palo Alto, CA, USA.
Jennifer ColonellJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Liu D LiuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Baylor College of Medicine, Houston, TX, USA.
Han HouJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Allen Institute for Neural Dynamics, Seattle, WA, USA.
Nai-Wen TienJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Tim WangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Allen Institute for Neural Dynamics, Seattle, WA, USA.
Timothy HarrisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Johns Hopkins University, Baltimore, MD, USA.
Shaul DruckmannJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Stanford University, Palo Alto, CA, USA. Electronic address: shauld@stanford.edu.
Nuo LiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Baylor College of Medicine, Houston, TX, USA. Electronic address: nuo.li@bcm.edu.
Karel SvobodaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Allen Institute for Neural Dynamics, Seattle, WA, USA. Electronic address: karel.svoboda@alleninstitute.org.
Howard Hughes Medical Institute · USPalo Alto University · US

Funding

Thalamus in the middle: computations in multi-regional neural circuitsU19NS123714 · NINDS · ALLEN INSTITUTE · PI Adam G Carter, Jayaram Chandrashekar · 2022 to 2026
$19.0M
Multi-regional neural circuit dynamics underlying short-term memoryR01NS113110 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DRUCKMANN, SHAUL, LI, NUO · 2019 to 2023
$3.2M
Cortico-cerebellar interactions underlying motor planning and movementR01NS112312 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI LI, NUO · 2019 to 2023
$1.8M
Dissecting modular and redundant organization of cortical circuitsRF1NS132025 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DRUCKMANN, SHAUL, LI, NUO · 2023 to 2024
$1.7M
Opponent control of action selection in the cortico-basal-ganglia-colliculus loopR01NS131229 · NINDS · DUKE UNIVERSITY · PI Nuo Li · 2023 to 2026
$1.6M
NINDS NIH HHS R01 NS112312NINDS NIH HHS R01 NS113110NINDS NIH HHS R01 NS131229NINDS NIH HHS RF1 NS132025NINDS NIH HHS U19 NS123714Wellcome Trust
6 · The paper itself

Abstract

Behavior relies on activity in structured neural circuits that are distributed across the brain, but most experiments probe neurons in a single area at a time. Using multiple Neuropixels probes, we recorded from multi-regional loops connected to the anterior lateral motor cortex (ALM), a circuit node mediating memory-guided directional licking. Neurons encoding sensory stimuli, choices, and actions were distributed across the brain. However, choice coding was concentrated in the ALM and subcortical areas receiving input from the ALM in an ALM-dependent manner. Diverse orofacial movements were encoded in the hindbrain; midbrain; and, to a lesser extent, forebrain. Choice signals were first detected in the ALM and the midbrain, followed by the thalamus and other brain areas. At movement initiation, choice-selective activity collapsed across the brain, followed by new activity patterns driving specific actions. Our experiments provide the foundation for neural circuit models of decision-making and movement initiation.

Indexed as

MovementNeuronsBrainMemoryThalamusbrain-widecodingdecision-makingmotor planningmovement initiationNeuropixels

Identifiers

PMID38306983
PMCPMC11492138
OpenAlexW4391450294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.