Evidence map›Paper›PMID 38306915›Full record

ReviewCurrent opinion in microbiology2024

Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum.

Ruth Lappalainen, Manish Kumar, Manoj T Duraisingh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ruth LappalainenDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston 02115, USA.
Manish KumarDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston 02115, USA.
Manoj T DuraisinghDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston 02115, USA. Electronic address: mduraisi@hsph.harvard.edu.
Harvard University · US

Funding

Functional analysis of epigenetic regulators of malaria blood-stage proliferation and transmissionR01AI138551 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2018 to 2022
$2.0M
Linking metabolite sensing and gene expression in malaria parasitesR21AI168806 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI DURAISINGH, MANOJ T · 2023 to 2024
$439k
NIAID NIH HHS R01 AI138551NIAID NIH HHS R21 AI168806
6 · The paper itself

Abstract

The human malaria parasite Plasmodium falciparum undergoes a complex life cycle in two hosts, mammalian and mosquito, where it is constantly subjected to environmental changes in nutrients. Epigenetic mechanisms govern transcriptional switches and are essential for parasite persistence and proliferation. Parasites infecting red blood cells are auxotrophic for several nutrients, and mounting evidence suggests that various metabolites act as direct substrates for epigenetic modifications, with their abundance directly relating to changes in parasite gene expression. Here, we review the latest understanding of metabolic changes that alter the histone code resulting in changes to transcriptional programmes in malaria parasites.

Indexed as

MalariaMalaria, FalciparumAnimalsChromatinEpigenesis, GeneticHumansMammalsPlasmodium falciparumChromatin

Identifiers

PMID38306915
PMCPMC11157454
OpenAlexW4391499949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.