ArticleJournal of the American Chemical Society2024
Exact and Ubiquitous Condition for Solid-State Deracemization in Vitro and in Nature.
Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- How Crystal Size and Number Steer Asymmetric Crystallization.The journal of physical chemistry letters · 2026Article
- Mechanistic Dissymmetry between Crystal Growth and Dissolution Drives Ratcheted Chiral Amplification.Journal of the American Chemical Society · 2025Article
- Spontaneous Emergence of Homochiral Suspensions from Racemic Solutions via Stochastic Nucleation.Journal of the American Chemical Society · 2025Article
- On Solute Recovery and Productivity in Chiral Resolution through Solid-State Deracemization by Temperature Cycling.Crystal growth & design · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solid-state deracemization is the amplification of an enantiomeric excess in suspensions of conglomerate-forming chiral compounds. Although numerous chemical and biochemical compounds deracemize, its governing mechanism has remained elusive. We introduce a novel formulation of the classical population-based model of deracemization through temperature cycles to prove that suspensions deracemize whenever a simple and ubiquitous condition is met: crystal dissolution must be faster than crystal growth. Such asymmetry is a known principle of crystallization, hence explaining the generality of deracemization. Through both experiments and a theoretical analysis, we demonstrate that this condition applies even for very small temperature cycles and for random temperature fluctuations. These findings establish solid-state deracemization as an attractive route to the manufacture of enantiopure products and as a plausible pathway toward the emergence of homochirality in nature.
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Registered trials
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