Evidence map›Paper›PMID 38306459›Full record

ArticleJournal of medical entomology2024

Phenotypic variation in biting behavior associated with differences in expression of olfactory genes in the vector mosquito, Aedes albopictus (Diptera: Culicidae).

Mara Heilig, Samantha L Sturiale, Sarah Marzec, Christina M Holzapfel, William E Bradshaw, Megan E Meuti, Peter A Armbruster

Open access · greenAbstract read
In one paragraph

Article in Journal of medical entomology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mara HeiligDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0009-0000-7756-577X
Samantha L SturialeDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0000-0002-6825-4133
Sarah MarzecDepartment of Biology, Georgetown University, Washington, DC, USA.
Christina M HolzapfelDepartment of Biology, Laboratory of Evolutionary Genetics, Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA.
William E BradshawDepartment of Biology, Laboratory of Evolutionary Genetics, Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA.
Megan E MeutiDepartment of Entomology, The Ohio State University, Columbus, OH, USA.
Peter A ArmbrusterDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0000-0002-8183-3842
Georgetown University · USUniversity of Oregon · USThe Ohio State University · US

Funding

Evolution of non-biting in mosquito disease vectorsR21AI144266 · NIAID · GEORGETOWN UNIVERSITY · PI ARMBRUSTER, PETER, HOLZAPFEL, CHRISTINA M. · 2019 to 2020
$444k
NIAID NIH HHS R21 AI144266NIH HHS R21-AI144266
6 · The paper itself

Abstract

We evaluated miRNA and mRNA expression differences in head tissues between avid-biting vs. reluctant-biting Aedes albopictus (Skuse) females from a single population over a 20-min timescale. We found no differences in miRNA expression between avid vs. reluctant biters, indicating that translational modulation of blood-feeding behavior occurs on a longer timescale than mRNA transcription. In contrast, we detected 19 differentially expressed mRNAs. Of the 19 differentially expressed genes at the mRNA level between avid-biting vs. reluctant-biting A. albopictus, 9 are implicated in olfaction, consistent with the well-documented role of olfaction in mosquito host-seeking. Additionally, several of the genes that we identified as differentially expressed in association with phenotypic variation in biting behavior share similar functions with or are inferred orthologues of, genes associated with evolutionary variation in biting behaviors of Wyeomyia smithii (Coq.) and Culex pipiens (Lin.). A future goal is to determine whether these genes are involved in the evolutionary transition from a biting to a non-biting life history.

Indexed as

AedesCulexMicroRNAsAnimalsBiological Variation, PopulationFemaleMosquito VectorsRNA, MessengerSmellMicroRNAsRNA, Messengerblood feedinghost-seekingmicroRNAolfaction

Identifiers

PMID38306459
PMCPMC10936175
OpenAlexW4391467287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.