ArticleJournal of Alzheimer's disease : JAD2024
Multimorbidity, Social Engagement, and Age-Related Cognitive Decline in Older Adults from the Rancho Bernardo Study of Healthy Aging.
Article in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 10 citations in OpenAlex.
- Multimorbidity, Polypharmacy, and Neighborhood Disadvantage as Determinants of Cognitive Performance in the ARCHES Cohort.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Multimorbidity patterns and cognitive trajectories in older adults: functional, behavioral, and environmental pathways-a longitudinal analysis of CHARLS.Research square · 2026Article
- Natriuretic Peptides as a Biomarker of Cognitive Decline in Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Review
- Interviews of community-dwelling older persons in Greece on healthy aging and wellbeing during multiple crises (the HAiG study).Frontiers in aging · 2026Article
- The global burden of hearing loss and its comorbidity with chronic diseases: a comprehensive analysis from 1990 to 2021.Scientific reports · 2025Article
- Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study.Aging clinical and experimental research · 2025Article
- Edentulism, social mobility, and cognitive aging: a life course perspective.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Experiences of Social Relationships for Adults Living With Multiple Long-Term Conditions: A Qualitative Interview Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Cohort Changes in Cognitive Function Among Mexican Older Adults from 2001 to 2021.The Gerontologist · 2025Article
- The multiple mediating roles of depression and grandchild care in the relationship between social participation and cognitive function among middle-aged and elderly Chinese: an empirical study based on CHARLS 2020 data.Frontiers in aging neuroscience · 2025Article
- Article
- Trajectory of Cognitive Decline Across Different Racial/Ethnic Groups: The Role of Edentulism.Research on agingArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Background: Multimorbidity is associated with increased rate of cognitive decline with age. It is unknown whether social engagement, which is associated with reduced risk of dementia, modifies associations between multimorbidity and cognitive decline. Objective: To examine the associations of multimorbidity with longitudinal cognitive test performance among community-dwelling older adults, and to determine whether associations differed by levels of social engagement. Methods: We used data from the Rancho Bernardo Study of Healthy Aging, a community-based prospective cohort study. Starting in 1992-1996, participants completed a battery of cognitive function tests at up to 6 study visits over 23.7 (mean = 7.2) years. Multimorbidity was defined as≥2 of 14 chronic diseases. Social engagement was assessed using items based on the Berkman-Syme Social Network Index. Multivariable linear mixed-effects models were used to test associations of multimorbidity and cognitive performance trajectories. Effect measure modification by social engagement was evaluated. Results: Among 1,381 participants (mean age = 74.5 years; 60.8% women; 98.8% non-Hispanic White), 37.1% had multimorbidity and 35.1% had low social engagement. Multimorbidity was associated with faster declines in Mini-Mental State Examination (MMSE; β= -0.20; 95% CI -0.35, -0.04), Trail-Making Test Part B (β= 10.02; 95% CI 5.77, 14.27), and Category Fluency (β= -0.42; 95% CI -0.72, -0.13) after adjustment for socio-demographic and health-related characteristics. Multimorbidity was associated with faster declines in MMSE among those with low compared to medium and high social engagement (p-interaction < 0.01). Conclusions: Multimorbidity was associated with faster declines in cognition among community-dwelling older adults. Higher social engagement may mitigate multimorbidity-associated cognitive decline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.