Evidence map›Paper›PMID 38305761›Full record

ReviewChemical Society reviews2024

Serum antibody screening using glycan arrays.

Samantha Marglous, Claire E Brown, Vered Padler-Karavani, Richard D Cummings, Jeffrey C Gildersleeve

Open access · greenAbstract readReview
In one paragraph

Review in Chemical Society reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Immunoproteomics: The Evolution from Classical Methods to Emerging Techniques.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Glycan microarray analysis ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Defined Glycan Ligands for Detecting Rare l-Sugar-Binding Proteins.Journal of the American Chemical Society · 2025
    Article
  16. Synthesis of Fluorinated Glycotope Mimetics Derived fromInternational journal of molecular sciences · 2025
    Article
  17. Current Landscape of Therapeutic Cancer Vaccines.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Samantha MarglousChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA. gildersj@mail.nih.gov.ORCID http://orcid.org/0000-0002-2892-6150
Claire E BrownChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA. gildersj@mail.nih.gov.ORCID http://orcid.org/0000-0002-1840-7840
Vered Padler-KaravaniDepartment of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel. vkaravani@tauex.tau.ac.il.ORCID http://orcid.org/0000-0002-4761-3571
Richard D CummingsDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. rcummin1@bidmc.harvard.edu.
Jeffrey C GildersleeveChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA. gildersj@mail.nih.gov.ORCID http://orcid.org/0000-0002-3744-6423
National Cancer Institute · USBeth Israel Deaconess Medical Center · USTel Aviv University · IL

Funding

Serum Antibody Profiling with a Carbohydrate MicroarrayZIABC011055 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILDERSLEEVE, JEFFREY · 2009 to 2025
$6.3M
Development of a Carbohydrate MicroarrayZIABC010675 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILDERSLEEVE, JEFFREY · 2009 to 2025
$6.1M
Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
European Research Council 101003021NIGMS NIH HHS R24 GM137763
6 · The paper itself

Abstract

Humans and other animals produce a diverse collection of antibodies, many of which bind to carbohydrate chains, referred to as glycans. These anti-glycan antibodies are a critical part of our immune systems' defenses. Whether induced by vaccination or natural exposure to a pathogen, anti-glycan antibodies can provide protection against infections and cancers. Alternatively, when an immune response goes awry, antibodies that recognize self-glycans can mediate autoimmune diseases. In any case, serum anti-glycan antibodies provide a rich source of information about a patient's overall health, vaccination history, and disease status. Glycan microarrays provide a high-throughput platform to rapidly interrogate serum anti-glycan antibodies and identify new biomarkers for a variety of conditions. In addition, glycan microarrays enable detailed analysis of the immune system's response to vaccines and other treatments. Herein we review applications of glycan microarray technology for serum anti-glycan antibody profiling.

Indexed as

PolysaccharidesVaccinesAnimalsAntibodiesCarbohydratesHumansMicroarray AnalysisAntibodiesCarbohydratesPolysaccharidesVaccines

Identifiers

PMID38305761
PMCPMC7616341
OpenAlexW4391494176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.