Evidence map›Paper›PMID 38305752›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2024

Unlocking the dark matter: noncoding RNAs and RNA modifications in cardiac aging.

Jiayi Kang, James Rhee, Chunyan Wang, Yolander Yang, Guoping Li, Haobo Li

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiayi KangDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
James RheeDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Chunyan WangDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Yolander YangDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Guoping LiDepartment of Anaesthesia, Harvard Medical School, Boston, Massachusetts, United States.
Haobo LiDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.ORCID 0000-0002-5660-7835
Harvard University · USMassachusetts General Hospital · US

Funding

The Role of Family with Sequence Similarity 3D (FAM3D) in Cardioprotection and Inflammation after Myocardial InfarctionK08HL140200 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RHEE, JAMES · 2019 to 2023
$864k
A Long Noncoding RNA SALTe Links Heart Failure to Alzheimer's DiseaseR21AG077040 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LI, HAOBO · 2022 to 2022
$446k
American Heart Association (AHA) 20CDA35310184American Heart Association (AHA) 23CDA1045944HHS | National Institutes of Health (NIH) K08HL140200HHS | National Institutes of Health (NIH) R21AG077040NHLBI NIH HHS K08 HL140200NIA NIH HHS R21 AG077040
6 · The paper itself

Abstract

Cardiac aging is a multifaceted process that encompasses structural and functional alterations culminating in heart failure. As the elderly population continues to expand, there is a growing urgent need for interventions to combat age-related cardiac functional decline. Noncoding RNAs have emerged as critical regulators of cellular and biochemical processes underlying cardiac disease. This review summarizes our current understanding of how noncoding RNAs function in the heart during aging, with particular emphasis on mechanisms of RNA modification that control their activity. Targeting noncoding RNAs as potential novel therapeutics in cardiac aging is also discussed.

Indexed as

Heart FailureRNA, Long NoncodingAgedAgingHeartHumansRNA, UntranslatedRNA, Long NoncodingRNA, Untranslatedaginglong noncoding RNAsmicroRNAnoncoding RNARNA modification

Identifiers

PMID38305752
PMCPMC11221808
OpenAlexW4391471483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.