Evidence map›Paper›PMID 38305157›Full record

ArticleJournal of medicinal chemistry2024

Preclinical Evaluation of Novel Positron Emission Tomography (PET) Probes for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2).

Zhen Chen, Jiahui Chen, Wakana Mori, Yongjia Yi, Jian Rong, Yinlong Li, Erick R Calderon Leon, Tuo Shao, Zhendong Song, Tomoteru Yamasaki and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Recent advances in [Nuclear medicine and biology · 2026
    Review
  2. Article
  3. Development ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Zhen ChenJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.ORCID 0000-0002-6289-4332
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States.ORCID 0000-0001-9186-1110
Wakana MoriDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Yongjia YiJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.
Jian RongDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States.ORCID 0000-0002-3960-1669
Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States.
Erick R Calderon LeonDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Tuo ShaoDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, United States.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States.
Tomoteru YamasakiDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Hideki IshiiDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Yiding ZhangDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Tomomi KokufutaDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Kuan HuDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.ORCID 0000-0003-2448-2254
Lin XieDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
Lee JosephsonDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, United States.
Richard VanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
Yihan ShaoDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID 0000-0001-9337-341X
Stewart FactorJean and Paul Amos Parkinson's Disease and Movement Disorder Program, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Ming-Rong ZhangDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.ORCID 0000-0002-3001-9605
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United States.ORCID 0000-0003-1413-6315
National Institutes for Quantum Science and Technology · JPHarvard University · USUniversity of Oklahoma · USEmory University · USNanjing Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most highly debilitating neurodegenerative disorders, which affects millions of people worldwide, and leucine-rich repeat kinase 2 (LRRK2) mutations have been involved in the pathogenesis of PD. Developing a potent LRRK2 positron emission tomography (PET) tracer would allow for in vivo visualization of LRRK2 distribution and expression in PD patients. In this work, we present the facile synthesis of two potent and selective LRRK2 radioligands [

Indexed as

MorpholinesNitrilesParkinson DiseasePyrimidinesAnimalsHumansLeucineLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMutationPositron-Emission Tomography(18F)PF-06455943LeucineLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanMorpholinesNitrilesPyrimidines

Identifiers

PMID38305157
PMCPMC10895652
OpenAlexW4391473272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.