Evidence map›Paper›PMID 38305096›Full record

ArticleJournal of applied microbiology2024

Evaluation of the safety and efficacy of fecal microbiota transplantations in bottlenose dolphins (Tursiops truncatus) using metagenomic sequencing.

Barbara K Linnehan, Sho M Kodera, Sarah M Allard, Erin C Brodie, Celeste Allaband, Rob Knight, Holly L Lutz, Maureen C Carroll, Jennifer M Meegan, Eric D Jensen and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Barbara K LinnehanNational Marine Mammal Foundation, San Diego, CA 92106, United States.ORCID 0000-0003-1560-3878
Sho M KoderaScripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, United States.ORCID 0000-0003-0451-0297
Sarah M AllardScripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, United States.
Erin C BrodieNational Marine Mammal Foundation, San Diego, CA 92106, United States.
Celeste AllabandDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, United States.ORCID 0000-0003-1832-4858
Rob KnightDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, United States.
Holly L LutzDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, United States.
Maureen C CarrollMSPCA Angell Animal Medical Center, Boston, MA 02130, United States.
Jennifer M MeeganNational Marine Mammal Foundation, San Diego, CA 92106, United States.
Eric D JensenU.S. Navy Marine Mammal Program, Naval Information Warfare Center Pacific, San Diego, CA 92106, United States.
Jack A GilbertScripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, United States.ORCID 0000-0001-7920-7001
National Marine Mammal Foundation · USScripps Institution of Oceanography · USUniversity of California San Diego · USMSPCA-Angell · USNaval Information Warfare Center Pacific · USScripps Research Institute · US

Funding

UCSD Research Training Program for VeterinariansT32OD017863 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, PETER B., SIGURDSON, CHRISTINA · 2014 to 2023
$2.0M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIH HHS #S10 OD026929NIH HHS S10 OD026929NIH HHS T32 OD017863
6 · The paper itself

Abstract

aimsGastrointestinal disease is a leading cause of morbidity in bottlenose dolphins (Tursiops truncatus) under managed care. Fecal microbiota transplantation (FMT) holds promise as a therapeutic tool to restore gut microbiota without antibiotic use. This prospective clinical study aimed to develop a screening protocol for FMT donors to ensure safety, determine an effective FMT administration protocol for managed dolphins, and evaluate the efficacy of FMTs in four recipient dolphins. METHODS AND

resultsComprehensive health monitoring was performed on donor and recipient dolphins. Fecal samples were collected before, during, and after FMT therapy. Screening of donor and recipient fecal samples was accomplished by in-house and reference lab diagnostic tests. Shotgun metagenomics was used for sequencing. Following FMT treatment, all four recipient communities experienced engraftment of novel microbial species from donor communities. Engraftment coincided with resolution of clinical signs and a sustained increase in alpha diversity.

conclusionThe donor screening protocol proved to be safe in this study and no adverse effects were observed in four recipient dolphins. Treatment coincided with improvement in clinical signs.

Indexed as

Bottle-Nosed DolphinGastrointestinal MicrobiomeAnimalsFecal Microbiota TransplantationFecesProspective StudiesTreatment Outcomefecal microbiota transplantationmicrobiomeshotgun metagenomicsTursiops truncatus

Identifiers

PMID38305096
PMCPMC10853691
OpenAlexW4391463699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.