ArticleAnnals of surgery2025
Postoperative Hyperamylasemia (POH) Is an Early Predictor of Pancreatic Fistula Occurrence and Severity After Distal Pancreatectomy: Results from a European Multicentric Study.
Article in Annals of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Clinical Evaluation of Postoperative Day 3 Serum Lipase in Relation to Clinically Relevant Pancreatic Fistula After Distal Pancreatectomy: A Retrospective Cohort Study.Biomedicines · 2026Article
- Postoperative hyperamylasemia-an early warning signal after distal pancreatectomy.Hepatobiliary surgery and nutrition · 2026Article
- "The Critical 18" of postoperative white blood cell count and C-reactive protein level predicts postoperative pancreatic fistula after distal pancreatectomy.Patient safety in surgery · 2026Article
- Postpancreatectomy acute pancreatitis after distal pancreatectomy: tri-institutional international cohort.BJS open · 2026Article
- A Multicenter, Single-Blind, Randomized Trial Comparing Stapler Closure With Clip-on-Staple Method Versus Stapler Closure Alone During Distal Pancreatectomy (CLIP-DP Trial).Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- Article
- Elevated Liver Enzymes Can Predict Complications Early After Pancreatic Resection.Journal of clinical medicine · 2026Article
- Analysis of Different Post-Operative Hyperamylasemia Criteria for Defining Post-Pancreatectomy Acute Pancreatitis After Distal Pancreatectomy-A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Advancements in postoperative pancreatic fistula: a comprehensive review of predictive factors, therapies, scoring systems and ongoing trials.eGastroenterology · 2025Review
Corrections and comments
- Commented on by
Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this international multicentric study is to characterize postoperative hyperamylasemia (POH) after distal pancreatectomy (DP), with particular focus on its relationship with postoperative pancreatic fistula (POPF) occurrence and severity.
backgroundThe clinical relevance of POH after DP and its relationship with the occurrence and severity of POPF have not been explored yet.
methodsAll patients undergoing DP for any indication between 2015 and 2021 at 3 European referral centers for pancreatic surgery were retrospectively analyzed. Drain fluid amylase, C-reactive protein, and serum amylase were examined from postoperative day (POD) 1 to 3. Biochemical leak, POPF, POH, and postpancreatectomy hemorrhage were defined and graded according to ISGPS definitions.
resultsIn total, 1192 patients were included. Overall rates of POH and POPF were 18% (n= 210) and 29% (n= 344), respectively. The presence of drain fluid amylase ≥2000 U/L on POD 1 (OR=2.11, 95% CI: 1.68-2.86), C-reactive protein ≥200 mg/L on POD 3 (OR=2.19, 95% CI: 1.68-2.86), and POH (OR=1.58, 95% CI: 1.14-2.19) were all independent early predictors of POPF (all P <0.01). The presence of POH almost doubled the rate of POPF (43% vs 26%, P <0.001), and higher POPF severity presented also higher POH rates (no POPF=12%; biochemical leak=19%; B POPF=24%; C POPF=52%). Among patients developing POPF, patients with POH had higher rates of postpancreatectomy hemorrhage (22% vs 9%, P =0.001), sepsis (24% vs 13%; P =0.011), reoperation (21% vs 8%; P < 0.01), and mortality (3% vs 0.3%; P =0.025).
conclusionsThe occurrence of POH is an early predictor of POPF and its severity after DP. The diagnosis of POH might define patients at higher risk for a complicated course, targeting them for prevention/mitigation strategies against pancreas-specific complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.